Flow Sensing of Single Cell by Graphene Transistor in a Microfluidic Channel

被引：92

作者：

Ang, Priscilla Kailian ^{[2
,3
]}

Li, Ang ^{[1
,4
,5
]}

Jaiswal, Manu ^{[2
]}

Wang, Yu ^{[2
]}

Hou, Han Wei ^{[4
,5
,6
]}

Thong, John T. L. ^{[8
]}

Lim, Chwee Teck ^{[1
,4
,5
,6
,7
]}

Loh, Kian Ping ^{[2
]}

机构：

[1] Singapore MIT Alliance Res & Technol SMART, Singapore 117456, Singapore

[2] Natl Univ Singapore, Dept Chem, Graphene Res Ctr, Singapore 117543, Singapore

[3] NUS Grad Sch Integrat Sci & Engn, Singapore 117597, Singapore

[4] Natl Univ Singapore, Div Bioengn, Singapore 117576, Singapore

[5] Natl Univ Singapore, Dept Mech Engn, Singapore 117576, Singapore

[6] Singapore MIT Alliance Res & Technol SMART, BioSyst & Micromech BioSyM IRG, Singapore 117543, Singapore

[7] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore

[8] Natl Univ Singapore, Dept Elect & Comp Engn, Singapore 117576, Singapore

来源：

NANO LETTERS | 2011年 / 11卷 / 12期

关键词：

Graphene; field-effect transistor; microfluidics; single cell detection; infectious disease; cell surface charge density; RED-BLOOD-CELLS; FALCIPARUM-INFECTED ERYTHROCYTES; PLASMODIUM-FALCIPARUM; MALARIA; MICROSCOPY; TRANSPORT;

D O I：

10.1021/nl202579k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The electronic properties of graphene are strongly influenced by electrostatic forces arising from long-range charge scatterers and by changes in the local dielectric environment. This makes graphene extremely sensitive to the surface charge density of cells interfacing with it Here, we developed a graphene transistor array integrated with microfluidic flow cytometry for the "flow-catch-release" sensing of malaria-infected red blood cells at the single-cell level. Malaria-infected red blood cells induce highly sensitive capacitively coupled changes in the conductivity of graphene. Together with the characteristic conductance dwell times, specific microscopic information about the disease state can be obtained.

引用

页码：5240 / 5246

页数：7

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