Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

被引：15

作者：

Lin Peng-Cheng ^{[1
]}

Ji Lin-Lin ^{[2
]}

Zhong Xiang-Jian ^{[2
]}

Li Jin-Jie ^{[2
]}

Wang Xin ^{[2
]}

Shang Xiao-Ya ^{[2
]}

Lin Sheng ^{[3
,4
]}

机构：

[1] Qinghai Univ Nationalities, Coll Pharmaceut Sci, Xining 810000, Qinghai, Peoples R China

[2] Beijing Union Univ, Beiijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

[3] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Cirsium setosum; Taraxastane-type triterpenoid; TNF-alpha secretion inhibitory activity; Cytotoxicity;

D O I：

10.1016/S1875-5364(19)30005-6

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Guided by TNF-alpha secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3 beta, 30-diol (1) and 22 alpha-hydroxy-20-taraxasten-30 beta, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-alpha secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 mu mol.L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.

引用

页码：22 / 26

页数：5

共 13 条

[1]

Commission of National pharmacopoeia, 2015, CHINESE PHARMACOPOEI, P48

[2] Taraxastane-type triterpenoids from Saussurea petrovii [J].

Dai, JQ ;

Zhao, CY ;

Zhang, Q ;

Liu, ZL ;

Zheng, RG ;

Yang, L .

PHYTOCHEMISTRY, 2001, 58 (07) :1107-1111

[3]

Fang Y, 2015, CN, Patent No. [105199911 A 20151230, 105199911]

[4] Glycosides from the stem bark of Fraxinus sieboldiana [J].

Lin, Sheng ;

Wang, Sujuan ;

Liu, Mingtao ;

Gan, Maoluo ;

Li, Shuai ;

Yang, Yongchun ;

Wang, Yinghong ;

He, Wenyi ;

Shi, Jiangong .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (05) :817-823

[5] Four new taraxastane-type triterpenoic acids from Cirsium setosum [J].

Luan, Na ;

Wei, Wen-Di ;

Wang, Ali ;

Wu, Xiu-Li ;

Qi, Yan ;

Li, Jin-Jie ;

Zheng, Jian-Quan ;

Shang, Xiao-Ya .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 18 (11) :1015-1023

[6]

Ma Qin-Ge, 2016, Zhongguo Zhong Yao Za Zhi, V41, P868, DOI 10.4268/cjcmm20160518

[7] Simultaneous analysis of 11 main active components in Cirsium setosum based on HPLC-ESI-MS/MS and combined with statistical methods [J].

Sun, Qian ;

Chang, Lu ;

Ren, Yanping ;

Cao, Liang ;

Sun, Yingguang ;

Du, Yingfeng ;

Shi, Xiaowei ;

Wang, Qiao ;

Zhang, Lantong .

JOURNAL OF SEPARATION SCIENCE, 2012, 35 (21) :2897-2907

[8]

Wang WQ, 2016, CN, Patent No. [105238628 A 20160113, 105238628]

[9]

Xi YJ, 2012, CN, Patent No. [102835527 A 20121226, 102835527]

[10]

Ye X., 1999, STEREOCHEMISTRY, P257

← 1 2 →