Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

被引：37

作者：

Ikeda, Masashi ^{[1
]}

Saito, Takeo ^{[1
]}

Kondo, Kenji ^{[1
]}

Iwata, Nakao ^{[1
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2018年 / 72卷 / 02期

关键词：

genetics; microarray; mood disorder; polymorphism; psychosis; MAJOR DEPRESSIVE DISORDER; PSYCHIATRIC-DISORDERS; SCHIZOPHRENIA; RISK; LOCI; IDENTIFICATION; HYPERLIPIDEMIA; INDIVIDUALS; ATTITUDES; VARIANTS;

D O I：

10.1111/pcn.12611

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.

引用

页码：52 / 63

页数：12

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