Neuronal Plasticity: Neuronal Organization is Associated with Neurological Disorders

被引:13
作者
Dhuriya, Yogesh Kumar [1 ]
Sharma, Divakar [2 ,3 ]
机构
[1] CSIR, Indian Inst Toxicol Res CSIR IITR Vishvigyan Bhaw, Dev Toxicol Lab, Syst Toxicol & Hlth Risk Assessment Grp, 31 Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India
[2] Natl JALMA Inst Leprosy & Other Mycobacterial Dis, Dept Biochem, Agra, Uttar Pradesh, India
[3] Indian Inst Technol Delhi IIT, Kusuma Sch Biol Sci KSBS, Mass Spectrometry Lab, CRF, Delhi 110016, India
关键词
Neuronal plasticity; Short-term plasticity; Long-term potentiation; Neurodegenerative diseases; AMPAR; NMDAR; LONG-TERM POTENTIATION; AMPA RECEPTOR TRAFFICKING; PRESYNAPTIC CALCIUM CURRENT; SYNAPTIC PLASTICITY; NMDA-RECEPTOR; STRUCTURAL PLASTICITY; TRANSMITTER RELEASE; GABA(A) RECEPTOR; CA2+ CHANNELS; KINASE-II;
D O I
10.1007/s12031-020-01555-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Stimuli from stressful events, attention in the classroom, and many other experiences affect the functionality of the brain by changing the structure or reorganizing the connections between neurons and their communication. Modification of the synaptic transmission is a vital mechanism for generating neural activity via internal or external stimuli. Neuronal plasticity is an important driving force in neuroscience research, as it is the basic process underlying learning and memory and is involved in many other functions including brain development and homeostasis, sensorial training, and recovery from brain injury. Indeed, neuronal plasticity has been explored in numerous studies, but it is still not clear how neuronal plasticity affects the physiology and morphology of the brain. Thus, unraveling the molecular mechanisms of neuronal plasticity is essential for understanding the operation of brain functions. In this timeline review, we discuss the molecular mechanisms underlying different forms of synaptic plasticity and their association with neurodegenerative/neurological disorders as a consequence of alterations in neuronal plasticity.
引用
收藏
页码:1684 / 1701
页数:18
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