PLLA scaffolds surface-engineered via poly (propylene imine) dendrimers for improvement on its biocompatibility/controlled pH biodegradability

被引：25
作者：
Ganjalinia, Atiyeah. [1 ]
Akbari, Somaye. [1 ]
Solouk, Atefeh. [2 ]
机构：
[1] Amirkabir Univ Technol, Tehran Polytech, Text Engn Dept, Tehran, Iran
[2] Amirkabir Univ Technol, Tehran Polytech, Dept Biomed Engn, Tehran, Iran
来源：
APPLIED SURFACE SCIENCE | 2017年 / 394卷
关键词：
Poly (L) lactic acid; Poly (propylene imine) dendrimer; Aminolysis; Biodegradability; Biocompatibility; pH Control; IN-VITRO; BIOMEDICAL APPLICATIONS; GELATIN IMMOBILIZATION; POLY(L-LACTIDE) FILM; FIBROUS SCAFFOLDS; PLASMA TREATMENT; DRUG-DELIVERY; GENE DELIVERY; ACID); POLYESTERS;
D O I：
10.1016/j.apsusc.2016.10.110
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Novel aminolyzed Poly (L) Lactic Acid (PLLA) films and electrospun nanofibrous scaffolds were fabricated and characterized as potential substrates for tissue engineering. The second generation polypropylene imine dendrimer (PPI-G2) was used as the aminolysis agent to functionalize the inert surface of PLLA substrates directly without any pre-modification process. The effect of the solvent type, G2 concentration, reaction temperature and time were studied by following weight reduction percentage, FTIR and contact angle measurements due to determined optimum conditions. In addition, the modified scaffolds abbreviated by PLLA/G2 were analyzed using mechanical properties, SEM images and dye assays as host-guest modeling. The results indicate that under the 0.5 (wt.%) G2 concentration, ethanol as the solvent, room temperature and 4 h of treatment, the optimum conditions were obtained. It was shown that the hydrophilic properties of PLLA/G2 were greatly enhanced. Also, pH value analysis revealed that after 4 weeks, the biodegradation of PLLA caused massive immune cells infusion and inflammation in the medium through increasing the acidic rate by secretion the lactic acid, whereas the PLLA/ G2 scaffolds greatly reduced and stabilize the acidic rate through aminolysis reaction. Finally, promoted cell adhesion and viability underlined the favorable properties of PLLA/G2 scaffolds as a biodegradable biomaterial for biomedical implants. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：446 / 456
页数：11
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