Low Glycated Hemoglobin and Liver Disease in the US Population

被引：29

作者：

Christman, Andrea L. ^{[1
,2
]}

Lazo, Mariana ^{[1
,2
]}

Clark, Jeanne M. ^{[1
,2
,3
]}

Selvin, Elizabeth ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

来源：

DIABETES CARE | 2011年 / 34卷 / 12期

基金：

美国国家卫生研究院;

关键词：

ADULTS; MORTALITY; LEVEL; RISK;

D O I：

10.2337/dc11-0944

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-To characterize the association of low HbA(1c) values (<4.0%) with liver enzymes and steatosis. RESEARCH DESIGN AND METHODS-Cross-sectional study of 12,533 participants without diabetes aged <20 years in the Third National Health and Nutrition Examination Survey (1988-1994). Logistic regression models were adjusted for demographic, lifestyle, and health status variables. RESULTS-HbA(1c) values ranged from 3.2 to 15.7%, and 84 participants had HbA(1c) <4.0% in the population (mean age 44, 52% female, 15% black or Hispanic). We observed J-shaped associations between HbA(1c) and liver enzymes and hepatic steatosis. In adjusted models, HbA(1c) <4.0% was strongly associated with elevated alanine aminotransferase (OR 3.62 [95% Cl 1.09-12.02]) and aspartate aminotransferase (6.80 [2.99-15.43]). CONCLUSIONS-Low HbA(1c) values were associated with liver enzymes and steatosis in the U.S. population. Liver disease may partially explain the association of HbA(1c) with mortality and other long-term outcomes.

引用

页码：2548 / 2550

页数：3

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