Probiotics and prebiotics: focus on psychiatric disorders - a systematic review

被引:70
作者
Barbosa, Renata S. D. [1 ,2 ]
Vieira-Coelho, Maria A. [2 ]
机构
[1] Univ Porto, Fac Med, Dept Biomed, Pharmacol & Therapeut Unit, P-4200319 Porto, Portugal
[2] Univ Porto, Fac Med, Dept Clin Neurosci & Mental Hlth, Porto, Portugal
关键词
gut-brain axis; microbiota; prebiotics; probiotics; psychiatric disorders; MAJOR DEPRESSIVE DISORDER; GUT MICROBIOTA; DOUBLE-BLIND; BRAIN; SCHIZOPHRENIA; AUTISM; SYMPTOMS; DEMENTIA; CHILDREN; ANXIETY;
D O I
10.1093/nutrit/nuz080
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Context: The gut-brain axis and microbial dysbiosis may play a role in psychiatric diseases. In this view, the gut microbiota has been considered a potential therapeutic target using probiotics and prebiotics. Objective: This systematic review aims to find the existing clinical evidence that may justify the use of probiotics or prebiotics in psychiatric patients. Data sources: PRISMA guidelines were followed for a systematic literature review of randomized controlled trials that assessed the effect of prebiotics or probiotics in patients diagnosed with a classified psychiatric disorder. Data extraction: From a total of 212 studies screened, 11 were included in the final systematic review. Quality assessment of the included trials was assessed by the Jadad scale. Results: Probiotics seem to offer some benefit in major depressive disorder and Alzheimer's disease. One study showed that probiotics reduced rehospitalization in patients with acute mania. In autism spectrum disorders, the results were controversial; however a single study found that early administration of probiotics showed a preventive role. No benefits were found for patients with schizophrenia. In most studies, no major adverse effects were reported. Conclusions: Although recent findings in specific psychiatric disorders are encouraging, the use of prebiotics and probiotics in clinical practice stills lacks sufficiently robust evidence.
引用
收藏
页码:437 / 450
页数:14
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