Regulation of TOR by small GTPases

被引：81
作者：
Duran, Raul V. [1 ]
Hall, Michael N. [1 ]
机构：
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
来源：
EMBO REPORTS | 2012年 / 13卷 / 02期
基金：
瑞士国家科学基金会;
关键词：
TOR; Rheb; Rag; RalA; Rac1; Ryh1; COMPLEX; 1; MTORC1; MAMMALIAN TARGET; PHOSPHOLIPASE-D; SACCHAROMYCES-CEREVISIAE; AMINO-ACIDS; FISSION YEAST; CELL-GROWTH; MEDIATED PHOSPHORYLATION; RAPAMYCIN-RESISTANCE; ACTIN CYTOSKELETON;
D O I：
10.1038/embor.2011.257
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases.
引用
收藏
页码：121 / 128
页数：8
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