Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways

被引：46
作者：
Yoon, Sonia S. [1 ]
Sun, Jun [1 ,2 ]
机构：
[1] Univ Rochester, Strong Mem Hosp, Univ Rochester Mediacal Ctr, Div Gastroenterol & Hepatol,Dept Med, Rochester, NY 14642 USA
[2] Univ Rochester, Dept Microbiol & Immunol, Rochester, NY 14642 USA
来源：
GASTROENTEROLOGY RESEARCH AND PRACTICE | 2011年 / 2011卷
基金：
美国国家卫生研究院;
关键词：
VITAMIN-D-RECEPTOR; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL EPITHELIAL-CELLS; COLI NISSLE 1917; DIFFICILE-ASSOCIATED DIARRHEA; RANDOMIZED CONTROLLED-TRIAL; HEAT-SHOCK PROTEINS; CROHNS-DISEASE; LACTOBACILLUS-GG; SACCHAROMYCES-BOULARDII;
D O I：
10.1155/2011/971938
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
There is increased investigation of the human microbiome as it relates to health and disease. Dysbiosis is implicated in various clinical conditions including inflammatory bowel disease (IBD). Probiotics have been explored as a potential treatment for IBD and other diseases. The mechanism of action for probiotics has yet to be fully elucidated. This paper discusses novel mechanisms of action for probiotics involving anti-inflammatory signaling pathways. We highlight recent progress in probiotics and nuclear receptor signaling, such as peroxisome-proliferator-activated receptor gamma (PPAR.) and vitamin D receptor (VDR). We also discuss future areas of investigation.
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页数：16
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