Endotoxic recognition molecules, Toll-like receptor 4-MD-2

被引：72
作者：
Miyake, K
机构：
[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Infect Genet, Tokyo 1088639, Japan
[2] JST Corp, Tokyo, Japan
来源：
SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 01期
关键词：
toll-like receptor (TLR); radioprotective 105 (RP105); MD-1; MD-2;
D O I：
10.1016/j.smim.2003.10.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toll-like receptors (TLRs) are innate pathogen recognition molecules for microbial products. Lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria, is one of the most potent microbial products. LPS is recognized by TLR4 and MD-2. TLR4 is a transmembrane protein, the extracellular domain of which is composed of a protein motif called leucine-rich repeats (LRR). MD-2 is an extracellular molecule that is associated with the extracellular LRR of TLR4. MD-2 has a role in cell surface expression of TLR4 and interaction with LPS. TLR4-MD-2 contributes to containment of infections by Gram-negative bacteria by activating immune responses. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：11 / 16
页数：6
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