Neural stem cell therapy aiming at better functional recovery after spinal cord injury

被引：81

作者：

Zhu, Yicheng ^{[1
]}

Uezono, Naohiro ^{[1
]}

Yasui, Tetsuro ^{[1
]}

Nakashima, Kinichi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Stem Cell Biol & Med, Fukuoka, Japan

来源：

DEVELOPMENTAL DYNAMICS | 2018年 / 247卷 / 01期

关键词：

spinal cord injury; neural stem cell; transplantation; neuronal relay; CENTRAL-NERVOUS-SYSTEM; LONG-DISTANCE GROWTH; STEM/PROGENITOR CELLS; INTRASPINAL TRANSPLANTATION; DIRECT CONVERSION; HUMAN FIBROBLASTS; BRAIN-INJURY; MOUSE MODEL; NEURONS; NEUROGENESIS;

D O I：

10.1002/dvdy.24558

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits. In this review, we discuss the recent breakthroughs in NSC transplantation therapy for SCI. Developmental Dynamics 247:75-84, 2018. (c) 2017 Wiley Periodicals, Inc.

引用

页码：75 / 84

页数：10

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