Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low sensitivity

被引：119

作者：

Doehla, M. ^{[1
]}

Boesecke, C. ^{[2
]}

Schulte, B. ^{[3
]}

Diegmann, C. ^{[1
]}

Sib, E. ^{[1
]}

Richter, E. ^{[3
]}

Eschbach-Bludau, M. ^{[3
]}

Aldabbagh, S. ^{[3
]}

Marx, B. ^{[3
]}

Eis-Huebinger, A-M ^{[3
]}

Schmithausen, R. M. ^{[1
]}

Streeck, H. ^{[3
]}

机构：

[1] Univ Bonn, Med Fac, Inst Hyg & Publ Hlth, One Hlth Dept, Venusberg Campus 1, D-53127 Bonn, Germany

[2] Univ Bonn, Med Fac, Infect Dis Dept, Clin Internal Med, Venusberg Campus 1, D-53127 Bonn, Germany

[3] Univ Bonn, Med Fac, Inst Virol, Venusberg Campus 1, D-53127 Bonn, Germany

来源：

PUBLIC HEALTH | 2020年 / 182卷

关键词：

SARS-CoV-2; COVID-19; Coronavirus; Rapid test; Outbreak;

D O I：

10.1016/j.puhe.2020.04.009

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: With the current SARS-CoV2 outbreak, countless tests need to be performed on potential symptomatic individuals, contacts and travellers. The gold standard is a quantitative polymerase chain reaction (qPCR)-based system taking several hours to confirm positivity. For effective public health containment measures, this time span is too long. We therefore evaluated a rapid test in a high-prevalence community setting. Study design: Thirty-nine randomly selected individuals at a COVID-19 screening centre were simultaneously tested via qPCR and a rapid test. Ten previously diagnosed individuals with known SARS-CoV-2 infection were also analysed. Methods: The evaluated rapid test is an IgG/IgM-based test for SARS-CoV-2 with a time to result of 20 min. Two drops of blood are needed for the test performance. Results: Of 49 individuals, 22 tested positive by repeated qPCR. In contrast, the rapid test detected only eight of those positive correctly (sensitivity: 36.4%). Of the 27 qPCR-negative individuals, 24 were detected correctly (specificity: 88.9%). Conclusion: Given the low sensitivity, we recommend not to rely on an antibody-based rapid test for public health measures such as community screenings. (C) 2020 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

引用

页码：170 / 172

页数：3

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