Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus

被引：58

作者：

Kanter, Ines C. ^{[1
]}

Huttner, Hagen B. ^{[1
]}

Staykov, Dimitre ^{[1
]}

Biermann, Teresa ^{[2
]}

Struffert, Tobias ^{[3
]}

Kerling, Frank ^{[1
]}

Hilz, Max-Josef ^{[1
]}

Schellinger, Peter D. ^{[1
]}

Schwab, Stefan ^{[1
]}

Bardutzky, Juergen ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Neurol, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Psychiat, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Div Neuroradiol, Dept Radiol, D-91054 Erlangen, Germany

来源：

EPILEPSIA | 2008年 / 49卷 / 05期

关键词：

anti-GAD antibodies; cyclophosphamide; epilepsy; intrathecal GAD-Ab synthesis;

D O I：

10.1111/j.1528-1167.2007.01500.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glutamic acid decarboxylase (GAD) is the enzyme which catalyzes the production of gamma aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system (CNS). There is increasing evidence that severe GAD autoimmunity may be associated with refractory epilepsy. Immunomodulation and GABAergic drugs have been suggested as treatment options. We report here for the first time on a patient with sudden onset of refractory status epilepticus in the presence of strong intrathecal anti-GAD antibody synthesis who was successfully treated with cyclophosphamide, and give an overview of available data on epilepsy associated with GAD autoimmunity.

引用

页码：914 / 920

页数：7

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