Engineered Multifunctional Nanocarriers for Cancer Diagnosis and Therapeutics

被引：82

作者：

Shi, Donglu ^{[1
,2
]}

Bedford, Nicholas M. ^{[2
]}

Cho, Hoon-Sung ^{[3
,4
]}

机构：

[1] Tongji Univ, Inst Adv Mat & Nano Biomed, Shanghai 200092, Peoples R China

[2] Univ Cincinnati, Dept Chem & Mat Engn, Cincinnati, OH 45221 USA

[3] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[4] Massachusetts Gen Hosp, Ctr Translat Nucl Med & Mol Imaging, Charlestown, MA 02129 USA

来源：

SMALL | 2011年 / 7卷 / 18期

关键词：

WALLED CARBON NANOTUBES; DIFFUSE OPTICAL TOMOGRAPHY; SEMICONDUCTOR QUANTUM DOTS; CONTROLLED DRUG-RELEASE; IN-VIVO; MAGNETIC NANOPARTICLES; BREAST-CANCER; IRON-OXIDE; PROSTATE-CANCER; MACROMOLECULAR THERAPEUTICS;

D O I：

10.1002/smll.201100436

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article reviews advances in the design and development of multifunctional carbon-based and/or magnetic nanoparticle systems (or simply 'nanocarriers') for early cancer diagnosis and spatially and temporally controlled therapy. The critical issues in cancer diagnosis and treatment are addressed based on novel nanotechnologies such as real-time in-vivo imaging, drug storage and release, and specific cancer-cell targeting. The implementation of nanocarriers into animal models and the subsequent effectiveness in treating tumors is also reviewed. Recommendations for future research are given.

引用

页码：2549 / 2567

页数：19

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