Hyperbaric oxygen in the treatment of postoperative infections in paediatric patients with neuromuscular spine deformity

被引:15
作者
Larsson, A. [1 ,2 ]
Uusijarvi, J. [1 ,2 ]
Lind, F. [1 ]
Gustavsson, B. [3 ]
Saraste, H. [4 ]
机构
[1] Karolinska Univ Hosp, Dept Anaesthesiol & Intens Care, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Physiol & Pharmacol, Sect Anaesthesia & Intens Care Med, Stockholm, Sweden
[3] Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden
[4] Karolinska Univ Hosp, Dept Orthopaed, Stockholm, Sweden
关键词
Hyperbaric oxygenation; Spine deformity; Postoperative infection; Tethered cord; Spinal implants; ANTIBIOTIC PENETRATION; COMPLICATIONS; THERAPY; CIPROFLOXACIN; LIMITATION; SCOLIOSIS; SURGERY; HYPOXIA; GROWTH;
D O I
10.1007/s00586-011-1797-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of this study is to evaluate possible benefits of hyperbaric oxygen (HBO) therapy in the treatment of deep postoperative infections in six high risk paediatric patients with neuromuscular spine deformity. The study involved review of medical records including radiology, office visits, and telephone contacts for six patients, referred for postoperative HBO therapy in 2003-2005. Infection control and healing without removal of implants or major revision surgery with a minimum of 2-year follow-up after index surgery were considered to represent success. All infections were resolved. Median time for wound healing, normalisation of blood tests and antibiotic weaning were 3 months. Radiological bony fusion, intact implants without any signs of radiolucent zones were seen in all cases at a mean follow-up of 54 months (37-72). Side effects of HBO treatment were minor. HBO is a safe and potentially useful adjuvance in the treatment of early deep postoperative infections in complex situations with spinal implants in high risk paediatric patients.
引用
收藏
页码:2217 / 2222
页数:6
相关论文
共 22 条
[1]  
Allen DB, 1997, ARCH SURG-CHICAGO, V132, P991
[2]   Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin [J].
Anderl, JN ;
Franklin, MJ ;
Stewart, PS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (07) :1818-1824
[3]   The outcome of scoliosis surgery in the severely physically handicapped child - An objective and subjective assessment [J].
Askin, GN ;
Hallett, R ;
Hare, N ;
Webb, JK .
SPINE, 1997, 22 (01) :44-50
[4]  
BENSON, 1998, SPINE, V23, P2318
[5]   Results and morbidity in a consecutive series of patients undergoing spinal fusion for neuromuscular scoliosis [J].
Benson, ER ;
Thomson, JD ;
Smith, BG ;
Banta, JV .
SPINE, 1998, 23 (21) :2308-2317
[6]  
Brismar K, 1997, Wound Repair Regen, V5, P147
[7]   Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS [J].
Buras, JA ;
Stahl, GL ;
Svoboda, KKH ;
Reenstra, WR .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2000, 278 (02) :C292-C302
[8]  
Granström G, 1998, ADV OTO-RHINO-LARYNG, V54, P33
[9]   Wounds: An overview of the role of oxygen [J].
Hopf, Harriet W. ;
Rollins, Mark D. .
ANTIOXIDANTS & REDOX SIGNALING, 2007, 9 (08) :1183-1192
[10]   Hyperoxia and angiogenesis [J].
Hopf, HW ;
Gibson, JJ ;
Angeles, AP ;
Constant, JS ;
Feng, JJ ;
Rollins, MD ;
Hussain, MZ ;
Hunt, TK .
WOUND REPAIR AND REGENERATION, 2005, 13 (06) :558-564