Thermosensitive Nanoparticles Based on Polyethylenimine as Promising Materials for Biomedical Applications

被引：0
作者：
Tenkovtsev, A. V. [1 ]
Kurlykin, M. P. [1 ]
Amirova, A. I. [1 ]
Krasova, A. S. [1 ]
Kirila, T. Yu. [1 ]
Filippov, A. P. [1 ]
机构：
[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 07期
基金：
俄罗斯科学基金会;
关键词：
polyethylenimine; thermosensitive polymers; nanopaticles; NONIONIC HYDROGEL; DRUG-DELIVERY;
D O I：
10.1134/S107036322007018X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Thermosensitive nanoparticles were synthesized by acylation of branched polyethyleneimine with isobutyroyl chloride and cross-linking by 1,6-hexamethylene diisocyanate. It was found that colloidal aqueous solutions of these particles reversibly lose solubility around physiological temperature. The influence of the composition of the nanoparticle on their hydrodynamic parameters, as well as on the phase transition temperatures in aqueous solutions was evaluated.
引用
收藏
页码：1312 / 1316
页数：5
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