Iridium-catalyzed orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions

被引：34

作者：

Li, Ming ^{[1
]}

Zheng, Nan ^{[1
]}

Li, Junhao ^{[1
]}

Zheng, Yubin ^{[1
]}

Song, Wangze ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Chem Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

GREEN CHEMISTRY | 2020年 / 22卷 / 08期

基金：

中国国家自然科学基金;

关键词：

AZIDE-ALKYNE CYCLOADDITION; UNSYMMETRICAL DISULFANES; ORGANIC-REACTIONS; WATER; 1,2,3-TRIAZOLES; COMPLEXES; DELIVERY; THIOLS; DRUG;

D O I：

10.1039/d0gc00555j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions has been developed. This simple and practical approach is environment-friendly and compatible with oxygen/water and various complex biological media. It features excellent regioselectivities and chemoselectivities, high yields, good biocompatibility and bioorthogonality. Its applications in the synthesis of carbohydrates and trigger-responsive nanoparticles are further highlights of this aqueous transformation.

引用

页码：2394 / 2398

页数：5

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