A Comprehensive Review on Novel Liposomal Methodologies, Commercial Formulations, Clinical Trials and Patents

被引：184

作者：

Andra, Veera Venkata Satya Naga Lakshmi ^{[1
]}

Bhatraju, Lakshmi Venkata Krishna Priya ^{[2
]}

Ruddaraju, Lakshmi Kalyani ^{[1
]}

机构：

[1] Shri Vishnu Coll Pharm, Dept Pharmaceut Sci, Bhimavaram 534201, Andhra Pradesh, India

[2] GMR Inst Technol GMRIT, Dept Basic Sci & Humanities, Rajam 532127, Andhra Pradesh, India

来源：

BIONANOSCIENCE | 2022年 / 12卷 / 01期

关键词：

Biological analysis; Drug delivery systems; Liposomes; Recent advancements; STABILITY; VESICLES; CAPTURE; TUMORS; DRUGS; CO2;

D O I：

10.1007/s12668-022-00941-x

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Liposomes are well-recognized and essential nano-sized drug delivery systems. Liposomes are phospholipid vesicles comprised of cell membrane components and have been employed as artificial cell models to mimic structure and functions of cells and are of immense use in various biological analyses. Liposomes acquire great advantages and provide wide range of applications as useful drug carriers in pre-clinical and clinical trials. This review summarizes exclusively on scalable techniques for liposome preparation and focuses on the strengths and limitations with respect to industrial applicability. Also, this review discusses the updated recent advancements in biomedical applications with a mention of key highlights of commercially available formulations, clinical trials and patents in recent past. Furthermore, this review also provides brief information of the classification, composition and characterization of liposomes.

引用

页码：274 / 291

页数：18

共 100 条

[1] Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release [J].

Aghdam, Marjan Abri ;

Bagheri, Roya ;

Mosafer, Jafar ;

Baradaran, Behzad ;

Hashemzaei, Mahmoud ;

Baghbanzadeh, Amir ;

de la Guardi, Miguel ;

Mokhtarzadeh, Ahad .

JOURNAL OF CONTROLLED RELEASE, 2019, 315 :1-22

[2] Liposome: classification, preparation, and applications [J].

Akbarzadeh, Abolfazl ;

Rezaei-Sadabady, Rogaie ;

Davaran, Soodabeh ;

Joo, Sang Woo ;

Zarghami, Nosratollah ;

Hanifehpour, Younes ;

Samiei, Mohammad ;

Kouhi, Mohammad ;

Nejati-Koshki, Kazem .

NANOSCALE RESEARCH LETTERS, 2013, 8

[3] The magnetic inorganic-organic nanocomposite based on ZnFe2O4-Imatinib-liposome for biomedical applications, in vivo and in vitro study [J].

Amiri, Mahnaz ;

Gholami, Tahereh ;

Amiri, Omid ;

Pardakhti, Abbas ;

Ahmadi, Meysam ;

Akbari, Ahmad ;

Amanatfard, Arezoo ;

Salavati-Niasari, Masoud .

JOURNAL OF ALLOYS AND COMPOUNDS, 2020, 849

[4] Radiolabeled liposomes and lipoproteins as lipidic nanoparticles for imaging and therapy [J].

Aranda-Lara, Liliana ;

Morales-Avila, Enrique ;

Luna-Gutierrez, Myrna A. ;

Olive-Alvarez, Eunice ;

Isaac-Olive, Keila .

CHEMISTRY AND PHYSICS OF LIPIDS, 2020, 230

[5] A novel approach to predict drugs solubility in supercritical solvents for RESS process using various cubic EoS-mixing rule [J].

Bagheri, Hamidreza ;

Mansoori, G. Ali ;

Hashemipour, Hassan .

JOURNAL OF MOLECULAR LIQUIDS, 2018, 261 :174-188

[6] Liposomes encapsulated iridium(III) polypyridyl complexes enhance anticancer activity in vitro and in vivo [J].

Bai, Lan ;

Fei, Wei-Dong ;

Gu, Yi-Ying ;

He, Miao ;

Du, Fan ;

Zhang, Wen-Yao ;

Yang, Lin-Lin ;

Liu, Yun-Jun .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2020, 205

[7] DIFFUSION OF UNIVALENT IONS ACROSS LAMELLAE OF SWOLLEN PHOSPHOLIPIDS [J].

BANGHAM, AD ;

STANDISH, MM ;

WATKINS, JC .

JOURNAL OF MOLECULAR BIOLOGY, 1965, 13 (01) :238-+

[8] ACTION OF STEROIDS AND STREPTOLYSIN S ON PERMEABILITY OF PHOSPHOLIPID STRUCTURES TO CATIONS [J].

BANGHAM, AD ;

STANDISH, MM ;

WEISSMANN, G .

JOURNAL OF MOLECULAR BIOLOGY, 1965, 13 (01) :253-+

[9] SINGLE BILAYER LIPOSOMES PREPARED WITHOUT SONICATION [J].

BATZRI, S ;

KORN, ED .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 298 (04) :1015-1019

[10] Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole [J].

Bezerra, Camila Fonseca ;

de Alencar Junior, Jose Geraldo ;

Honorato, Rosilaine de Lima ;

Lucas dos Santos, Antonia Thassya ;

Pereira da Silva, Josefa Carolaine ;

da Silva, Tais Gusmao ;

Alves Borges Leal, Antonio Linkoln ;

Rocha, Janaina Esmeraldo ;

de Freitas, Thiago Sampaio ;

Tavares Vieira, Thiago Adler ;

Fonseca Bezerra, Maria Clara ;

Sales, Debora Lima ;

Kerntopf, Marta Regina ;

Delmondes, Gyllyandeson de Araujo ;

Barbosa Filho, Jose Maria ;

Peixoto, Laisla Rangel ;

Pinheiro, Allyson Pontes ;

Ribeiro-Filho, Jaime ;

Melo Coutinho, Henrique Douglas ;

Bezerra Morais-Braga, Maria Flaviana ;

da Silva, Teresinha Goncalves .

CHEMISTRY AND PHYSICS OF LIPIDS, 2020, 233

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