Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb

被引：35
作者：
Zhang, Yi [1 ]
Yu, Hai-Yang [1 ]
Chao, Li-Ping [2 ]
Qu, Lu [1 ]
Ruan, Jing-Ya [2 ]
Liu, Yan-Xia [1 ]
Dong, Yong-Zhe [2 ]
Han, Li-Feng [2 ]
Wang, Tao [1 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshan Rd, Tianjin 300193, Peoples R China
来源：
STEROIDS | 2016年 / 112卷
关键词：
Dioscorea septemloba Thunb; Steroids; Anti-inflammatory activity; GLYCOSIDES; SAPONINS;
D O I：
10.1016/j.steroids.2016.05.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven new steroid glycosides, dioscorosides A(1) (1), A(2) (2), B-1 (3), B-2 (4), C-1 (5), C-2 (6), and D (7), together with 22 known ones (8-29) were isolated from the rhizomes of Dioscorea septemloba, their structures were elucidated by chemical and spectroscopic methods. All isolates were evaluated for in vitro anti-inflammatory potential using LPS-stimulated RAW 264.7 murine macrophages. Among, them,, spirostane glycosides 18 and 21-24 exhibited significant inhibition of nitrite production. Moreover, the structure activity relationship was summarized. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：95 / 102
页数：8
相关论文
共 50 条
[41]   Norclerodane diterpenoids from rhizomes of Dioscorea bulbifera [J].
Liu, Hai ;
Chou, Gui-Xin ;
Guo, Yin-Long ;
Ji, Li-Li ;
Wang, Jun-Ming ;
Wang, Zheng-Tao .
PHYTOCHEMISTRY, 2010, 71 (10) :1174-1180
[42]   Steroids with potential anti-inflammatory activity from the roots of Datura metel L. [J].
Liu, Yan ;
Guan, Wei ;
Yang, Chun-li ;
Luo, Yu-meng ;
Liu, Yuan ;
Zhou, Yuan-yuan ;
Liu, Li-na ;
Yang, Bing-you ;
Kuang, Hai-xue .
CANADIAN JOURNAL OF CHEMISTRY, 2020, 98 (02) :74-78
[43]   Hyjapones A - D, trimethylated acyphloroglucinol meroterpenoids from Hypericum japonicum thunb. With anti-inflammatory activity [J].
Deng, Xin ;
Xia, Jing ;
Hu, Bo ;
Hou, Xing-cun ;
Pu, Xiang-dong ;
Wu, Lin .
PHYTOCHEMISTRY, 2022, 202
[44]   Anti-inflammatory neolignans from Epimedium pseudowushanese [J].
Ti, Huihui ;
Wu, Ping ;
Xu, Liangxiong ;
Wei, Xiaoyi .
NATURAL PRODUCT RESEARCH, 2017, 31 (22) :2621-2628
[45]   Anti-Inflammatory Saponins From an Edible Aquatic Plant Nymphoides hydrophylla [J].
Chen, Ching-Yeu ;
Cheng, Tzu-Peng ;
Hwang, Tsong-Long ;
Hou, Yong-Siang ;
Salendra, Limbadri ;
Ke, Tzi-Yi ;
Cheng, Yuan-Bin .
PHYTOCHEMICAL ANALYSIS, 2025,
[46]   Chemical Constituents from the Roots and Rhizomes of Asarum heterotropoides var. mandshuricum and the In Vitro Anti-Inflammatory Activity [J].
Jing, Yu ;
Zhang, Yi-Fan ;
Shang, Ming-Ying ;
Liu, Guang-Xue ;
Li, Yao-Li ;
Wang, Xuan ;
Cai, Shao-Qing .
MOLECULES, 2017, 22 (01)
[47]   Six pairs of enantiomeric phthalide dimers from the rhizomes of Ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities [J].
Huang, Lu ;
Peng, Cheng ;
Guo, Li ;
Feng, Rui ;
Shu, Hong-Zhen ;
Tian, Yun-Cai ;
Zhou, Qin-Mei ;
Xiong, Liang .
BIOORGANIC CHEMISTRY, 2022, 127
[48]   Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities [J].
Semwal, Ruchi Badoni ;
Semwal, Deepak Kumar ;
Semwal, Ravindra ;
Singh, Randhir ;
Rawat, Mohan Singh Maniyari .
JOURNAL OF ETHNOPHARMACOLOGY, 2011, 135 (01) :78-87
[49]   Pregnane C21-Steroids with Anti-Inflammatory Activity from the Roots of Cynanchum bungei [J].
Li, Xiao-San ;
Zhang, Ai-Ling ;
Yuan, Wei-Bin ;
Feng, Wan-Bi ;
Zheng, Tong-Xin ;
Cai, Hai-Tao ;
Lin, Zi-Xin ;
Zhang, Yu-Bo ;
Lan, Cai-Yun ;
Yan, Chong .
CHEMISTRY & BIODIVERSITY, 2025, 22 (05)
[50]   Steroids block the anti-inflammatory effects of low level laser therapy [J].
Brandao Lopes-Martins, Rodrigo Alvaro ;
Albertini, Regiane ;
Sardinha Leonardo Lopes-Martins, Patricia ;
Vereide Iversen, Vegard ;
Bjordal, Jan Magnus .
MECHANISMS FOR LOW LIGHT THERAPY, 2006, 6140
12345