Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb

被引：35
作者：
Zhang, Yi [1 ]
Yu, Hai-Yang [1 ]
Chao, Li-Ping [2 ]
Qu, Lu [1 ]
Ruan, Jing-Ya [2 ]
Liu, Yan-Xia [1 ]
Dong, Yong-Zhe [2 ]
Han, Li-Feng [2 ]
Wang, Tao [1 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshan Rd, Tianjin 300193, Peoples R China
来源：
STEROIDS | 2016年 / 112卷
关键词：
Dioscorea septemloba Thunb; Steroids; Anti-inflammatory activity; GLYCOSIDES; SAPONINS;
D O I：
10.1016/j.steroids.2016.05.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven new steroid glycosides, dioscorosides A(1) (1), A(2) (2), B-1 (3), B-2 (4), C-1 (5), C-2 (6), and D (7), together with 22 known ones (8-29) were isolated from the rhizomes of Dioscorea septemloba, their structures were elucidated by chemical and spectroscopic methods. All isolates were evaluated for in vitro anti-inflammatory potential using LPS-stimulated RAW 264.7 murine macrophages. Among, them,, spirostane glycosides 18 and 21-24 exhibited significant inhibition of nitrite production. Moreover, the structure activity relationship was summarized. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：95 / 102
页数：8
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