Organocatalytic direct difluoromethylation of aldehydes and ketones with TMSCF2H

被引：33

作者：

Du, Guang-Fen ^{[1
,2
]}

Wang, Ying ^{[1
]}

Gu, Cheng-Zhi ^{[1
]}

Dai, Bin ^{[1
]}

He, Lin ^{[1
]}

机构：

[1] Shihezi Univ, Sch Chem & Chem Engn, Xinjiang Uygur 832000, Peoples R China

[2] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 45期

基金：

中国国家自然科学基金;

关键词：

LEWIS-BASE CATALYST; CARBONYL-COMPOUNDS; NUCLEOPHILIC DIFLUOROMETHYLATION; DEPROTONATIVE FUNCTIONALIZATION; STEREOSELECTIVE-SYNTHESIS; ORGANOZINC REAGENTS; S(N)2' REACTION; ALKYL-HALIDES; T-BU-P4; BASE; TRIFLUOROMETHYLATION;

D O I：

10.1039/c5ra04472c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An organic Lewis base promoted direct difluoromethylation reaction of carbonyl compounds with Me3SiCF2H has been studied. The Schwesinger's superbase can efficiently activate the Si-CF2H bond and initiate the difluoromethylation of aldehydes and ketones under very mild conditions, producing difluoromethyl adducts in 42-99% yields.

引用

页码：35421 / 35424

页数：4

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