Synthesis and biological activity of potential antiviral compounds through 1,3-dipolar cycloadditions; Part 1: general aspects and reactions of azides

被引：3

作者：

Faita, Giuseppe ^{[1
]}

Leusciatti, Marco ^{[1
]}

Quadrelli, Paolo ^{[1
]}

机构：

[1] Univ Pavia, Dept Chem, Viale Taramelli 12, I-27100 Pavia, Italy

来源：

ARKIVOC | 2022年

关键词：

Antivirals; 3-Dipolar cycloadditions; Azides; Synthesis; Biological evaluation; Nucleosides; ANTI-HIV ACTIVITY; ASSISTED CLICK CHEMISTRY; NUCLEOSIDE ANALOGS; PHENYLALANINE DERIVATIVES; CYTOTOXIC EVALUATION; NUCLEOTIDE ANALOGS; INFLUENZA-A; DESIGN; INHIBITORS; ACID;

D O I：

10.24820/ark.5550190.p011.794

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Prominent in the current stage of drug development, antiviral compounds can be efficiently prepared through cycloaddition reactions. This review reports the use of 1,3-dipolar cycloaddition reactions of selected 1,3dipoles, in particular azides, in the light of their application for the preparation of key intermediates in the design and synthesis of compounds that were tested for their antiviral activities against a variety of viruses. The products obtained from these pericyclic reaction approaches were tested for their activities in terms of blocking the virus replication and the relevant biological data are highlighted.

引用

页码：19 / 78

页数：60

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