Alcohol Effects on Cerebral Blood Flow in Subjects With Low and High Responses to Alcohol

被引:57
作者
Tolentino, Neil J. [1 ]
Wierenga, Christina E. [1 ,3 ]
Hall, Shana [1 ]
Tapert, Susan F. [1 ,3 ]
Paulus, Martin P. [1 ,3 ]
Liu, Thomas T. [2 ]
Smith, Tom L. [1 ]
Schuckit, Marc A. [1 ]
机构
[1] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[2] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA
[3] VA San Diego Healthcare Syst, San Diego, CA USA
关键词
Alcohol; Arterial Spin Labeling; Level of Response to Alcohol; Alcoholism Risk; PERFUSION MRI; UNITED-STATES; USE DISORDERS; ETHANOL; LEVEL; BRAIN; SONS; BOLD; SENSITIVITY; ACTIVATION;
D O I
10.1111/j.1530-0277.2011.01435.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: Although there are multiple indications that alcohol can alter many physiological brain functions, including cerebral blood flow (CBF), studies of the latter have generally used small- or modest-sized samples. Few investigations have yet evaluated how CBF changes after alcohol relate to subsets of subjects with elevated alcoholism risks, such as those with lower levels of response (LR) to alcohol. This study used arterial spin labeling (ASL) after alcohol administration to evaluate a large sample of healthy young men and women with low and high alcohol responses, and, thus, varying risks for alcohol use disorders (AUD). Methods: Healthy young adult social drinkers with low and high LR (N = 88, 50% women) matched on demography and drinking histories were imaged with whole-brain resting ASL similar to 1 hour after ingesting similar to 3 drinks of ethanol and after a placebo beverage (i.e., 178 ASL sessions). The relationships of CBF changes from placebo to alcohol for subjects with low and high LR were evaluated. Results: CBF increased after alcohol when compared to placebo in 5 frontal brain regions. Despite identical blood alcohol concentrations, these increases with alcohol were less prominent in individuals who required more drinks to experience alcohol-related effects (i.e., had a lower LR to alcohol). The LR group differences remained significant after covarying for recent drinking quantities. Conclusions: The results confirm that alcohol intake is associated with acute increases in CBF, particularly in frontal regions. Less intense CBF changes were seen in subjects with a genetically influenced characteristic, a low LR to alcohol, that relates to the future risk of heavy drinking and alcohol problems.
引用
收藏
页码:1034 / 1040
页数:7
相关论文
共 56 条
[1]   Cerebral blood flow and dynamic cerebral autoregulation during ethanol intoxication and hypercapnia [J].
Blaha, M ;
Aaslid, R ;
Douville, CM ;
Correra, R ;
Newell, DW .
JOURNAL OF CLINICAL NEUROSCIENCE, 2003, 10 (02) :195-198
[2]   The efficacy of 2 different dosages of methylphenidate in treating adults with attention-deficit hyperactivity disorder [J].
Bouffard, R ;
Hechtman, L ;
Minde, K ;
Iaboni-Kassab, F .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2003, 48 (08) :546-554
[3]   BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: Differential relationship to global perfusion [J].
Brown, GG ;
Zorrilla, LTE ;
Georgy, B ;
Kindermann, SS ;
Wong, EC ;
Buxton, RB .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (07) :829-837
[4]   A NEW, SEMISTRUCTURED PSYCHIATRIC INTERVIEW FOR USE IN GENETIC-LINKAGE STUDIES - A REPORT ON THE RELIABILITY OF THE SSAGA [J].
BUCHOLZ, KK ;
CADORET, R ;
CLONINGER, CR ;
DINWIDDIE, SH ;
HESSELBROCK, VM ;
NURNBERGER, JI ;
REICH, T ;
SCHMIDT, I ;
SCHUCKIT, MA .
JOURNAL OF STUDIES ON ALCOHOL, 1994, 55 (02) :149-158
[5]   Modeling the hemodynamic response to brain activation [J].
Buxton, RB ;
Uludag, K ;
Dubowitz, DJ ;
Liu, TT .
NEUROIMAGE, 2004, 23 :S220-S233
[6]   Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling [J].
Chalela, JA ;
Alsop, DC ;
Gonzalez-Atavales, JB ;
Maldjian, JA ;
Kasner, SE ;
Detre, JA .
STROKE, 2000, 31 (03) :680-687
[7]   Subjective Stimulant and Sedative Effects of Alcohol During Early Drinking Experiences Predict Alcohol Involvement in Treated Adolescents [J].
Chung, Tammy ;
Martin, Christopher S. .
JOURNAL OF STUDIES ON ALCOHOL AND DRUGS, 2009, 70 (05) :660-667
[8]   Decreased perfusion in young alcohol-dependent women as compared with age-matched controls [J].
Clark, Camellia P. ;
Brown, Gregory G. ;
Eyler, Lisa T. ;
Drummond, Sean P. A. ;
Braun, Deborah R. ;
Tapert, Susan F. .
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 2007, 33 (01) :13-19
[9]   Effect of basal conditions on the magnitude and dynamics of the blood oxygenation level-dependent fMRI response [J].
Cohen, ER ;
Ugurbil, K ;
Kim, SG .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2002, 22 (09) :1042-1053
[10]   AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages [J].
Cox, RW .
COMPUTERS AND BIOMEDICAL RESEARCH, 1996, 29 (03) :162-173