From cytogenetics to next-generation sequencing technologies: advances in the detection of genome rearrangements in tumors

被引：26

作者：

Morozova, Olena ^{[1
,2
]}

Marra, Marco A. ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada

[2] Natl Canc Inst Canada, Vancouver, BC, Canada

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2008年 / 86卷 / 02期

关键词：

genome rearrangement; cancer; next-generation sequencing; copy number variation;

D O I：

10.1139/O08-003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome rearrangements have long been recognized as hallmarks of human tumors and have been used to diagnose cancer. Techniques used to detect genome rearrangements have evolved from microscopic examinations of chromosomes to the more recent microarray-based approaches. The availability of next-generation sequencing technologies may provide a means for scrutinizing entire cancer genomes and transcriptomes at unparalleled resolution. Here we review the methods that have been used to detect genome rearrangements and discuss the scope and limitations of each approach. We end with a discussion of the potential that next-generation sequencing technologies may offer to the field.

引用

页码：81 / 91

页数：11

共 101 条

[1]

Al-Hajj M, 2007, CURR OPIN ONCOL, V19, P61

[2] The detection of large deletions or duplications in genomic DNA [J].

Armour, JAL ;

Barton, DE ;

Cockburn, DJ ;

Taylor, GR .

HUMAN MUTATION, 2002, 20 (05) :325-337

[3] Measurement of locus copy number by hybridisation with amplifiable probes [J].

Armour, JAL ;

Sismani, C ;

Patsalis, PC ;

Cross, G .

NUCLEIC ACIDS RESEARCH, 2000, 28 (02) :605-609

[4] Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach [J].

Bainbridge, Matthew N. ;

Warren, Rene L. ;

Hirst, Martin ;

Romanuik, Tammy ;

Zeng, Thomas ;

Go, Anne ;

Delaney, Allen ;

Griffith, Malachi ;

Hickenbotham, Matthew ;

Magrini, Vincent ;

Mardis, Elaine R. ;

Sadar, Marianne D. ;

Siddiqui, Asim S. ;

Marra, Marco A. ;

Jones, Steven J. M. .

BMC GENOMICS, 2006, 7 (1)

[5] PCR AMPLIFICATION OF UP TO 35-KB DNA WITH HIGH-FIDELITY AND HIGH-YIELD FROM LAMBDA-BACTERIOPHAGE TEMPLATES [J].

BARNES, WM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :2216-2220

[6] Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data [J].

Baross, Agnes ;

Delaney, Allen D. ;

Li, H. Irene ;

Nayar, Tarun ;

Flibotte, Stephane ;

Qian, Hong ;

Chan, Susanna Y. ;

Asano, Jennifer ;

Ally, Adrian ;

Cao, Manqiu ;

Birch, Patricia ;

Brown-John, Mabel ;

Fernandes, Nicole ;

Go, Anne ;

Kennedy, Giulia ;

Langlois, Sylvie ;

Eydoux, Patrice ;

Friedman, J. M. ;

Marra, Marco A. .

BMC BIOINFORMATICS, 2007, 8 (1)

[7] Application and interpretation of FISH in biomarker studies [J].

Bayani, Jane ;

Squire, Jeremy A. .

CANCER LETTERS, 2007, 249 (01) :97-109

[8] ABSOLUTE MESSENGER-RNA QUANTIFICATION USING THE POLYMERASE CHAIN-REACTION (PCR) - A NOVEL-APPROACH BY A PCR AIDED TRANSCRIPT TITRATION ASSAY (PATTY) [J].

BECKERANDRE, M ;

HAHLBROCK, K .

NUCLEIC ACIDS RESEARCH, 1989, 17 (22) :9437-9446

[9] High-resolution analysis of DNA copy number using oligonucleotide microarrays [J].

Bignell, GR ;

Huang, J ;

Greshock, J ;

Watt, S ;

Butler, A ;

West, S ;

Grigorova, M ;

Jones, KW ;

Wei, W ;

Stratton, MR ;

Futreal, PA ;

Weber, B ;

Shapero, MH ;

Wooster, R .

GENOME RESEARCH, 2004, 14 (02) :287-295

[10] Quantitative real-time PCR for quick simultaneous determination of therapy-stratifying markers MYCN amplification, deletion 1p and 11q [J].

Boensch, M ;

Oberthuer, A ;

Fischer, M ;

Skowron, M ;

Oestreich, J ;

Berthold, F ;

Spitz, R .

DIAGNOSTIC MOLECULAR PATHOLOGY, 2005, 14 (03) :177-182

← 1 2 3 4 5 6 7 8 9 10 →