Epigenetic modifications in gastric cancer: Focus on DNA methylation

被引：63
作者：
Ebrahimi, Vida [1 ,2 ]
Soleimanian, Alireza [1 ,3 ]
Ebrahimi, Tahereh [4 ]
Azargun, Robab [5 ]
Yazdani, Parivar [1 ]
Eyvazi, Shirin [6 ]
Tarhriz, Vahideh [1 ]
机构：
[1] Tabriz Univ Med Sci, Mol Med Res Ctr, Biomed Inst, Tabriz, Iran
[2] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Tehran, Iran
[3] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Tabriz, Iran
[4] Pasteur Inst Iran, Res Ctr, Dept NanoBiotechnol, Tehran, Iran
[5] Maragheh Univ Med Sci, Fac Med, Dept Microbiol, Maragheh, Iran
[6] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Biotechnol, Tehran, Iran
来源：
GENE | 2020年 / 742卷
关键词：
Gastric cancer; Epigenetics alterations; DNA methylation; TUMOR-SUPPRESSOR; PROMOTER METHYLATION; GENE METHYLATION; POOR SURVIVAL; E-CADHERIN; DIFFUSE; CARCINOGENESIS; METASTASIS; INVASION; PROLIFERATION;
D O I：
10.1016/j.gene.2020.144577
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Gastric cancer is a complex heterogeneous disease which is the fourth prevalent malignancy worldwide. Although, several diagnosis and treatment are available for the gastric cancer patients, however the malignancy is still the third leading cause of cancer-related death in the world. Beside the genetic and environmental factors, epigenetic alterations are also involved in the emergence of gastric cancer. Epigenetics alterations are heritable changes which regulate gene expression without occurring changes in DNA sequence. Epigenetic changes mostly include DNA methylation, histon post-translational modifications, chromatin remodeling and non-coding RNAs. Among the mentioned epigenetic modifications, DNA methylation is a major epigenetic process that plays a key role in different stages of evolution and cancer development. In this review, we address all types of related epigenetic modifications in gastric cancer by focus on DNA methylation by reviewing the recent literatures. Understanding of molecular mechanisms of epigenetics alterations in gastric cancer development helps researchers to identify new epigenetic drugs against the malignancy.
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页数：7
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