Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma

被引：40

作者：

Luther, C ^{[1
]}

Poeschel, S ^{[1
]}

Varga, M ^{[1
]}

Melms, A ^{[1
]}

Tolosa, E ^{[1
]}

机构：

[1] Univ Tubingen Hosp, Dept Gen Neurol, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 164卷 / 1-2期

关键词：

myasthenia gravis; regulatory T cells; thymus;

D O I：

10.1016/j.jneuroim.2005.03.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naturally occurring CD4(+)CD25(+) regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4(+)CD25(+) thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：124 / 128

页数：5

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