Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

被引：50

作者：

Peterson, Martha L. ^{[1
,2
]}

Ma, Chunhong ^{[3
]}

Spear, Brett T. ^{[1
,2
]}

机构：

[1] Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40536 USA

[2] Univ Kentucky, Markey Canc Ctr, Lexington, KY 40536 USA

[3] Shandong Univ, Sch Med, Inst Immunol, Jinan 250012, Shandong, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2011年 / 21卷 / 01期

关键词：

Alpha-fetoprotein; Hepatocellular carcinoma; Transcription; Liver; Development; Mouse; HUMAN HEPATOCELLULAR-CARCINOMA; HEPATOCYTE NUCLEAR FACTOR-3; TISSUE-SPECIFIC TRANSCRIPTION; FINGER PROTEIN ZBTB20; HEREDITARY PERSISTENCE; BINDING-PROTEIN; ZINC-FINGERS; CHROMOSOMAL LOCATION; NEGATIVE REGULATION; ENHANCER ELEMENTS;

D O I：

10.1016/j.semcancer.2011.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：21 / 27

页数：7

共 91 条

[41] A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma [J].

Keng, Vincent W. ;

Villanueva, Augusto ;

Chiang, Derek Y. ;

Dupuy, Adam J. ;

Ryan, Barbara J. ;

Matise, Ilze ;

Silverstein, Kevin A. T. ;

Sarver, Aaron ;

Starr, Timothy K. ;

Akagi, Keiko ;

Tessarollo, Lino ;

Collier, Lara S. ;

Powers, Scott ;

Lowe, Scott W. ;

Jenkins, Nancy A. ;

Copeland, Neal G. ;

Llovet, Josep M. ;

Largaespada, David A. .

NATURE BIOTECHNOLOGY, 2009, 27 (03) :264-274

[42] Promoter usage and alternative splicing [J].

Kornblihtt, AR .

CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (03) :262-268

[43] Tissue-specific transcription factors in progression of epithelial tumors [J].

Lazarevich, N. L. ;

Fleishman, D. I. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (05) :573-591

[44]

Lazarevich NL, 2000, BIOCHEMISTRY-MOSCOW+, V65, P117

[45] A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells [J].

Lee, JS ;

Heo, J ;

Libbrecht, L ;

Chu, IS ;

Kaposi-Novak, P ;

Calvisi, DF ;

Mikaelyan, A ;

Roberts, LR ;

Demetris, AJ ;

Sun, ZT ;

Nevens, F ;

Roskams, T ;

Thorgeirsson, SS .

NATURE MEDICINE, 2006, 12 (04) :410-416

[46]

Lee KC, 1999, MOL CELL BIOL, V19, P1279

[47]

Li M, 2010, INT J CANC

[48] ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome [J].

Liu, Gang ;

Clement, Lionel C. ;

Kanwar, Yashpal S. ;

Avila-Casado, Carmen ;

Chugh, Sumant S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (51) :39681-39692

[49]

Liu H, 2010, DNA CELL BIOL

[50] Striking differences between the mouse and the human α-fetoprotein enhancers [J].

Long, LY ;

Davidson, JN ;

Spear, BT .

GENOMICS, 2004, 83 (04) :694-705

← 1 2 3 4 5 6 7 8 9 10 →