Protection of COVID-19 vaccination and previous infection against Omicron BA.1, BA.2 and Delta SARS-CoV-2 infections

被引：91

作者：

Andeweg, Stijn P. ^{[1
]}

de Gier, Brechje ^{[1
]}

Eggink, Dirk ^{[1
]}

van den Ende, Caroline ^{[1
]}

van Maarseveen, Noortje ^{[2
,3
]}

Ali, Lubna ^{[2
]}

Vlaemynck, Boris ^{[4
]}

Schepers, Raf ^{[4
]}

Hahne, Susan J. M. ^{[1
]}

Reusken, Chantal B. E. M. ^{[1
]}

de Melker, Hester E. ^{[1
]}

van den Hof, Susan ^{[1
]}

Knol, Mirjam J. ^{[1
]}

机构：

[1] Ctr Infect Dis Control, Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[2] Saltro Diagnost Ctr Primary Care, Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[4] SYNLAB, Heppignies, Belgium

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

关键词：

D O I：

10.1038/s41467-022-31838-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The protection of COVID-19 vaccines against emerging variants needs to be monitored. Here, the authors use community testing data from the Netherlands and find that protection against infection by Omicron subvariants BA.1 and 2 is low and that booster vaccines considerably but temporarily increase protection. Given the emergence of the SARS-CoV-2 Omicron BA.1 and BA.2 variants and the roll-out of booster COVID-19 vaccination, evidence is needed on protection conferred by primary vaccination, booster vaccination and previous SARS-CoV-2 infection by variant. We employed a test-negative design on S-gene target failure data from community PCR testing in the Netherlands from 22 November 2021 to 31 March 2022 (n = 671,763). Previous infection, primary vaccination or both protected well against Delta infection. Protection against Omicron BA.1 infection was much lower compared to Delta. Protection was similar against Omicron BA.1 compared to BA.2 infection after previous infection, primary and booster vaccination. Higher protection was observed against all variants in individuals with both vaccination and previous infection compared with either one. Protection against all variants decreased over time since last vaccination or infection. We found that primary vaccination with current COVID-19 vaccines and previous SARS-CoV-2 infections offered low protection against Omicron BA.1 and BA.2 infection. Booster vaccination considerably increased protection against Omicron infection, but decreased rapidly after vaccination.

引用

页数：9

共 27 条

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