Transcription regulation through promoter-proximal pausing of RNA polymerase II

被引：294

作者：

Core, Leighton J. ^{[1
]}

Lis, John T. ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

SCIENCE | 2008年 / 319卷 / 5871期

关键词：

D O I：

10.1126/science.1150843

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.

引用

页码：1791 / 1792

页数：2

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