In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis

被引：35

作者：

Xie, JP

Yue, J

Xiong, YL

Wang, WY

Yu, SQ

Wang, HH ^{[1
]}

机构：

[1] Fudan Univ, Sch Life Sci, Inst Genet, Shanghai 200433, Peoples R China

[2] SW Normal Univ, Sch Life Sci, Inst Modern Biopharmaceut, Chongqing 400715, Peoples R China

[3] Shanghai Pulm Hosp, Shanghai 200433, Peoples R China

[4] Kunming Inst Zool, Lab Anim Toxin, Kunming 650223, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2003年 / 22卷 / 02期

关键词：

Mycobacterium tuberculosis; multidrug resistance; snake venom; small peptide; Naja atra;

D O I：

10.1016/S0924-8579(03)00110-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The recent re-emergence of tuberculosis, especially the multidrug-resistant cases, has highlighted the importance of screening effective novel drugs against Mycobacterium tuberculosis. In this study, the in vitro activities of small peptides isolated from snake venom were investigated against multidrug-resistant M. tuberculosis. Minimum inhibitory concentrations (MICs) were determined by the Bactec TB-460 radiometric method. A small peptide with the amino acid sequence ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGG (designated as vgf-1) from Naja atra (isolated from Yunnan province of China) venom had in vitro activity against clinically isolated multidrug-resistant strains of M. tuberculosis. The MIC was 8.5 mg/l. The antimycobacterial domain of this 60aa peptide is under investigation. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：172 / 174

页数：3

共 10 条

[1] Identification of an anti-mycobacterial domain in NK-lysin and granulysin [J].