Inflammation in human adipose tissues-Shades of gray, rather than white and brown

被引：13
作者：
Rakotoarivelo, Volatiana [1 ,2 ]
Variya, Bhavesh [1 ,2 ]
Ilangumaran, Subburaj [1 ,2 ]
Langlois, Marie-France [2 ,3 ]
Ramanathan, Sheela [1 ,2 ]
机构：
[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Anat & Cell Biol, 3001 North 12th Ave, Sherbrooke, PQ J1H 5N4, Canada
[2] CRCHUS, Sherbrooke, PQ, Canada
[3] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Sherbrooke, PQ, Canada
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2018年 / 44卷
基金：
加拿大健康研究院;
关键词：
Human obesity; Cytokines; Inflammation; Adipose tissues; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; DIET-INDUCED OBESITY; C-REACTIVE PROTEIN; ALTERNATIVELY ACTIVATED MACROPHAGES; ENDOPLASMIC-RETICULUM STRESS; HEPATIC INSULIN-RESISTANCE; INDUCED WEIGHT-LOSS; FACTOR-ALPHA; TNF-ALPHA;
D O I：
10.1016/j.cytogfr.2018.10.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic inflammation in adipose tissues has been associated with obesity and metabolic syndrome over the years. Various studies using animal models have contributed to our knowledge on the pro- and anti-inflammatory mediators that regulate obesity. Analyses of cytokine profiles in humans have not revealed a clear scenario. Likewise, treatments targeting inflammation to control obesity and insulin resistance has not yielded promising results. In this review we summarize the data available in human obesity and discuss the possible reasons that could explain the difficulties in treating obesity and insulin resistance by targeting pro-in-flammatory cytokines.
引用
收藏
页码：28 / 37
页数：10
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