The art and design of genetic screens: Mouse

被引：71
作者：
Kile, BT [1 ]
Hilton, DJ [1 ]
机构：
[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Canc & Hematol, Parkville, Vic 3050, Australia
来源：
NATURE REVIEWS GENETICS | 2005年 / 6卷 / 07期
基金：
澳大利亚研究理事会; 美国国家卫生研究院; 英国医学研究理事会;
关键词：
D O I：
10.1038/nrg1636
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Humans are mammals, not bacteria or plants, yeast or nematodes, insects or fish. Mice are also mammals, but unlike gorilla and goat, fox and ferret, giraffe and jackal, they are suited perfectly to the laboratory environment and genetic experimentation. In this review, we will summarize the tools, tricks and techniques for executing forward genetic screens in the mouse and argue that this approach is now accessible to most biologists, rather than being the sole domain of large national facilities and specialized genetics laboratories.
引用
收藏
页码：557 / 567
页数：11
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