Oxysterols from a Marine Sponge Inflatella sp and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease

被引：11
作者：
Kolesnikova, Sophia A. [1 ]
Lyakhova, Ekaterina G. [1 ]
Kalinovsky, Anatoly I. [1 ]
Popov, Roman S. [1 ]
Yurchenko, Ekaterina A. [1 ]
Stonik, Valentin A. [1 ,2 ]
机构：
[1] GB Elyakov Pacific Inst Bioorgan Chem PIBOC, Prospect 100 Let Vladivostoku 159, Vladivostok 690022, Russia
[2] Far Eastern Fed Univ, Sch Nat Sci, Sukhanova St 8, Vladivostok 690000, Russia
来源：
MARINE DRUGS | 2018年 / 16卷 / 11期
基金：
俄罗斯科学基金会;
关键词：
secondary metabolites; oxygenated steroids; marine sponge; Inflatella; NMR; ROS; Parkinson's disease; structure-activity relationship; SH-SY5Y CELLS; CHOLESTEROL; METABOLITES; STEROLS; RESVERATROL; INVOLVEMENT; APOPTOSIS; PRODUCTS;
D O I：
10.3390/md16110458
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new oxysterols 1-4 along with previously known oxygenated sterols 5-14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1-4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 1-14 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated.
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页数：12
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