Role of multiple factors likely contributing to severity-mortality of COVID-19

被引：11
|
作者：
Singh, Jasdeep [1 ]
Alam, Anwar [2 ]
Samal, Jasmine [2 ]
Maeurer, Markus [3 ,4 ,5 ,6 ]
Ehtesham, Nasreen Z. [2 ]
Chakaya, Jeremiah [5 ,6 ,7 ]
Hira, Subhash [8 ]
Hasnain, Seyed E. [1 ,9 ]
机构：
[1] Indian Inst Technol Delhi, Dept Biochem Engn & Biotechnol, New Delhi, India
[2] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi, India
[3] Champalimaud Ctr Unknown, ImmunoSurg Unit, Lisbon, Portugal
[4] Johannes Gutenberg Univ Mainz, Med Klin, Mainz, Germany
[5] UCL, Div Infect & Immun, London, England
[6] Univ Coll London Hosp, NIHR Biomed Res Ctr, London, England
[7] Kenyatta Univ, Dept Med Therapeut Dermatol & Psychiat, Nairobi, Kenya
[8] Univ Washington Seattle, Dept Global Hlth, Seattle, WA 98195 USA
[9] Sharda Univ, Dept Life Sci, Sch Basic Sci & Res, Greater Noida, Uttar Pradesh, India
来源：
INFECTION GENETICS AND EVOLUTION | 2021年 / 96卷
关键词：
COVID-19; SARS-CoV-2; Human behaviour; ACE2; Diabetes; Trained immunity; Immuno-nutrition; SARS-COV-2; SPIKE; BCG VACCINATION; ACE2; TRANSMISSION; INFECTIONS; INFANTS;
D O I：
10.1016/j.meegid.2021.105101
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
COVID-19 stalled the world in 2020 and continues to be the greatest health crisis of this generation. While the apparent case fatality rates across fluctuates around -2% globally, associated mortality/death rate (deaths per million population) varies distinctly across regions from the global average of -600 per million population. Heterogeneous factors have been linked with COVID-19 associated mortalities and these include age, share of geriatric population, comorbidities, trained immunity and climatic conditions. Apart from direct or indirect role of endemic diseases, dietary factors and host immunity in regulating COVID-19 severity, human behaviour will inevitably control outcome of this pandemic. Comprehensive understanding of these factors will have a bearing on management of future health crises.
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页数：5
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