Effect of Enteral Protein Amount on Growth and Health Outcomes in Very-Low-Birth-Weight Preterm Infants: Phase II of the Pre-B Project and an Evidence Analysis Center Systematic Review

被引:9
作者
Fenton, Tanis R. [1 ,2 ]
Groh-Wargo, Sharon [3 ,4 ]
Gura, Kathleen [5 ]
Martin, Camilia R. [6 ,7 ,8 ]
Taylor, Sarah N. [9 ,10 ]
Griffin, Ian J. [11 ,12 ]
Rozga, Mary [13 ]
Moloney, Lisa [13 ]
机构
[1] Univ Calgary, Cumming Sch Med, Alberta Children's Hosp, Res Inst,Community Hlth Sci,Inst Publ Hlth, Calgary, AB, Canada
[2] Alberta Hlth Serv, Canada Nutr Serv, Calgary, AB, Canada
[3] Case Western Reserve Univ, MetroHlth Med Ctr, Dept Nutr, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, MetroHlth Med Ctr, Dept Pediat, Cleveland, OH 44106 USA
[5] Boston Childrens Hosp, Clin Res Program, Dept Pharm, Boston, MA USA
[6] Harvard Med Sch, Pediat, Boston, MA 02115 USA
[7] Beth Israel Deaconess Med Ctr, Dept Neonatol, Neonatal Intens Care Unit, Boston, MA 02215 USA
[8] Beth Israel Deaconess Med Ctr, Div Translat Res, Boston, MA 02215 USA
[9] Yale Sch Med, Div Neonatol, New Haven, CT USA
[10] Yale Sch Med, Dept Pediat, New Haven, CT USA
[11] Biomed Res Inst New Jersey, Clin & Translat Res, Cedar Knolls, NJ USA
[12] Morristown Med Ctr, Dept Pediat, Morristown, NJ USA
[13] Evidence Anal Ctr, Acad Nutr & Dietet, 120 S Riverside Plaza,Suite 2190, Chicago, IL 60606 USA
关键词
SUPPORT PRACTICE GUIDELINES; PREMATURE-INFANTS; NUTRITIONAL CARE; QUALITY; NEEDS;
D O I
10.1016/j.jand.2020.11.002
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Adequate protein intake by very-low-birth-weight preterm infants (<= 1,500 g at birth) is essential to optimize growth and development. The estimated needs for this population are the highest of all humans, however, the recommended intake has varied greatly over the past several years. A literature search was conducted in PubMed, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Cochrane Central databases to identify randomized controlled trials evaluating the effect of prescribed protein intake and identified outcomes. Articles were screened by 2 reviewers, risk of bias was assessed, data were synthesized quantitatively and narratively, and each outcome was separately graded for certainty of evidence. The literature search retrieved 25,384 articles and 2 trials were included in final analysis. No trials were identified that evaluated effect of protein amount on morbidities or mortality. Moderate certainty evidence found a significant difference in weight gain when protein intake of greater than 3.5 g/kg/day from preterm infant formula was compared with lower intakes. Low-certainty evidence found no evidence of effect of protein intake of 2.6 vs 3.1 vs 3.8 g/kg/day on length, head circumference, skinfold measurements, or mid-arm circumference. Low-certainty evidence found some improvement in development measures when higher protein intake of 3.8 vs 3.1 vs 2.6 g/kg/day were compared. Low-certainty evidence found no significant difference in bone mineral content when these protein intakes were compared. No studies were identified that compared protein intake greater than 4.0 g/kg/day. This systematic review found that protein intake between 3.5 and 4.0 g/kg/day promotes weight gain and improved development.
引用
收藏
页码:2287 / +
页数:26
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