Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

被引：15
作者：
Cubillos, M
Alba, MP
Bermúdez, A
Trujillo, M
Patarroyo, ME
机构：
[1] FIDIC, Bogota 2600, Colombia
[2] Univ Nacl Colombia, Bogota, Colombia
来源：
BIOCHIMIE | 2003年 / 85卷 / 07期
关键词：
malaria; peptides; SERA protein; structure; vaccine;
D O I：
10.1016/S0300-9084(03)00136-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water: trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：651 / 657
页数：7
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