Trained Immunity as an Adaptive Branch of Innate Immunity

被引：14

作者：

Vetvicka, Vaclav ^{[1
]}

Sima, Petr ^{[2
]}

Vannucci, Luca ^{[2
]}

机构：

[1] Univ Louisville, Dept Pathol, Louisville, KY 40202 USA

[2] CAS, Inst Microbiol, Lab Immunotherapy, Prague 14220, Czech Republic

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期

关键词：

trained immunity; glucan; macrophages; NK cells; basophils; CANDIDA-ALBICANS; BCG VACCINATION; LYMPHOID-CELLS; BETA-GLUCAN; CYTOKINE PRODUCTION; CALMETTE-GUERIN; LOW-VIRULENCE; MEMORY; INFECTION; PROTECTION;

D O I：

10.3390/ijms221910684

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concept of trained immunity has become one of the most interesting and potentially commercially and clinically relevant ideas of current immunology. Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily monocytes/macrophages and natural killer (NK) cells, and is less specific than adaptive immunity; therefore, it may cross-protect against other infectious agents. It remains possible, however, that some of the observed changes are simply caused by increased levels of immune reactions resulting from supplementation with immunomodulators, such as glucan. In addition, the question of whether we can talk about trained immunity in cells with a life span of only few days is still unresolved.</p>

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页数：13

相关论文

共 113 条

[1] Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function [J].

Adams, Kevin ;

Weber, K. Scott ;

Johnson, Steven M. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (22) :1-26

[2] Oral administration of Debaryomyces hansenii CBS8339-β-glucan induces trained immunity in newborn goats [J].

Angulo, Miriam ;

Reyes-Becerril, Martha ;

Cepeda-Palacios, Ramon ;

Angulo, Carlos .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2020, 105

[3] BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity [J].

Arts, Rob J. W. ;

Moorlag, Simone J. C. F. M. ;

Novakovic, Boris ;

Li, Yang ;

Wang, Shuang-Yin ;

Oosting, Marije ;

Kumar, Vinod ;

Xavier, Ramnik J. ;

Wijmenga, Cisca ;

Joosten, Leo A. B. ;

Reusken, Chantal B. E. M. ;

Benn, Christine S. ;

Aaby, Peter ;

Koopmans, Marion P. ;

Stunnenberg, Hendrik G. ;

van Crevel, Reinout ;

Netea, Mihai G. .

CELL HOST & MICROBE, 2018, 23 (01) :89-+

[4] Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity [J].

Arts, Rob J. W. ;

Novakovic, Boris ;

ter Horst, Rob ;

Carvalho, Agostinho ;

Bekkering, Siroon ;

Lachmandas, Ekta ;

Rodrigues, Fernando ;

Silvestre, Ricardo ;

Cheng, Shih-Chin ;

Wang, Shuang-Yin ;

Habibi, Ehsan ;

Goncalves, Luis G. ;

Mesquita, Ines ;

Cunha, Cristina ;

van Laarhoven, Arjan ;

van de Veerdonk, Frank L. ;

Williams, David L. ;

van der Meer, Jos W. M. ;

Logie, Colin ;

O'Neill, Luke A. ;

Dinarello, Charles A. ;

Riksen, Niels P. ;

van Crevel, Reinout ;

Clish, Clary ;

Notebaart, Richard A. ;

Joosten, Leo A. B. ;

Stunnenberg, Hendrik G. ;

Xavier, Ramnik J. ;

Netea, Mihai G. .

CELL METABOLISM, 2016, 24 (06) :807-819

[5] Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection [J].

Askenase, Michael H. ;

Han, Seong-Ji ;

Byrd, Allyson L. ;

da Fonseca, Denise Morais ;

Bouladoux, Nicolas ;

Wilhelm, Christoph ;

Konkel, Joanne E. ;

Hand, Timothy W. ;

Lacerda-Queiroz, Norinne ;

Su, Xin-zhuan ;

Trinchieri, Giorgio ;

Grainger, John R. ;

Belkaid, Yasmine .

IMMUNITY, 2015, 42 (06) :1130-1142

[6] Innate lymphoid cell function in the context of adaptive immunity [J].

Bando, Jennifer K. ;

Colonna, Marco .

NATURE IMMUNOLOGY, 2016, 17 (07) :783-789

[7] Herpesvirus latency confers symbiotic protection from bacterial infection [J].

Barton, Erik S. ;

White, Douglas W. ;

Cathelyn, Jason S. ;

Brett-McClellan, Kelly A. ;

Engle, Michael ;

Diamond, Michael S. ;

Miller, Virginia L. ;

Virgin, Herbert W. .

NATURE, 2007, 447 (7142) :326-U7

[8] Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes [J].

Bekkering, Siroon ;

Quintin, Jessica ;

Joosten, Leo A. B. ;

van der Meer, Jos W. M. ;

Netea, Mihai G. ;

Riksen, Niels P. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (08) :1731-+

[9] EVIDENCE FOR MACROPHAGE-MEDIATED PROTECTION AGAINST LETHAL CANDIDA-ALBICANS INFECTION [J].

BISTONI, F ;

VECCHIARELLI, A ;

CENCI, E ;

PUCCETTI, P ;

MARCONI, P ;

CASSONE, A .

INFECTION AND IMMUNITY, 1986, 51 (02) :668-674

[10]

BISTONI F, 1988, J MED VET MYCOL, V26, P285

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