Selecting Rational Drug Combinations in Epilepsy

被引：19

作者：

Abou-Khalil, Bassel ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Nashville, TN 37235 USA

来源：

CNS DRUGS | 2017年 / 31卷 / 10期

关键词：

NEWLY-DIAGNOSED EPILEPSY; TONIC-CLONIC SEIZURES; CONTROLLED-RELEASE CARBAMAZEPINE; PARTIAL-ONSET SEIZURES; IDIOPATHIC GENERALIZED EPILEPSY; RANDOMIZED CONTROLLED-TRIAL; COMPLEX PARTIAL SEIZURES; PLACEBO-CONTROLLED TRIAL; NON-INFERIORITY TRIAL; ADD-ON THERAPY;

D O I：

10.1007/s40263-017-0471-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Monotherapy remains the standard initial therapy of epilepsy, but when the first antiepileptic drug (AED) fails, combination therapy may be considered. The choice of combination therapy should take into consideration pharmacokinetic interactions, as well as pharmacodynamic interactions related to mechanism of action. There is evidence that an AED combination with different mechanisms of action is more likely to be successful than a combination with the same mechanisms. The combination of lamotrigine and valproate has been demonstrated to be synergistic in its efficacy. However, there are limited data to support other synergistic AED combinations.

引用

页码：835 / 844

页数：10

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