Preparation of pH and temperature sensitive microspheres having magnetic properties and controlled drug delivery system

被引：0
|
作者：
Doksoz, Derman [1 ]
Tasdelen, Betul [1 ]
机构：
[1] Namik Kemal Univ, Biyomed Muhendisligi Bolumu, Tekirdag, Turkey
来源：
2017 ELECTRIC ELECTRONICS, COMPUTER SCIENCE, BIOMEDICAL ENGINEERINGS' MEETING (EBBT) | 2017年
关键词：
N-isopropylacrylamide; itaconic acid; magnetic; drug; microsphere;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this study, thermoresponsive hydrogel microspheres, namely, poly(N-isopropylacrylamide) (PNIPAAm) were prepared by using an inverse suspension polymerization technique. The radiation-induced modification of PNIPAAm microspheres with itaconic acid (IA) was applied for synthesizing pH and thermoresponsive PNIPAAm-co-poly(itaconic acid) microspheres (PNIPAAm-co-PIA). The PNIPAAM-co-PIA microspheres were simply immersed with iron (Fe2+, Fe3+) ions. In order to investigate drug release behavior of the prepared microspheres, 5-Fluorouracil as a model drug, namely, anti-cancer drug.
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页数：3
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