Synthesis of 5-hydroxy- and 5-sulfanyl-substituted [1,2,3]triazolo[4,5-e][1,4]diazepines

被引：3

作者：

Kemskiy, Sergiy V. ^{[1
]}

Syrota, Natalia A. ^{[2
]}

Bol'but, Andriy V. ^{[1
,3
]}

Dorokhov, Viktor I. ^{[1
]}

Vovk, Mykhaylo V. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Organ Chem, 5 Murmanska St, UA-02094 Kiev, Ukraine

[2] Natl Univ Kyiv Mohyla Acad, 2 Hryhoriya Skovorody St, UA-04655 Kiev, Ukraine

[3] Enamine Ltd, 78 Chervonotkatska St, UA-02094 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 08期

关键词：

5-amino-N-(2,2-dimethoxyethyl)-1H-1,2,3-triazole-4-carboxamides; 1,2,3] triazolo[4,5-e][1,4] diazepines; intramolecular cyclization; thiofunctionalization; GUANASE; AZEPINOMYCIN; INHIBITORS; ANALOGS; ANESTHESIA;

D O I：

10.1007/s10593-018-2350-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Amino-N-(2,2-dimethoxyethyl)-1H-1,2,3-triazole-4-carboxamides in formic acid were subjected to intramolecular cyclization to 5-hydroxy[1,2,3] triazolo[4,5-e][1,4] diazepines, which were converted by treatment with S-nucleophiles to 5-thio-functionalized derivatives.

引用

页码：789 / 795

页数：7

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