Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach

被引：25
作者：
Koulousakis, Philippos [1 ,2 ,3 ]
van den Hove, Daniel [3 ,4 ]
Visser-Vandewalle, Veerle [1 ,2 ]
Sesia, Thibaut [1 ,2 ]
机构：
[1] Univ Hosp Cologne, Dept Stereotact & Funct Neurosurg, Kerpener Str 62, D-50937 Cologne, Germany
[2] European Grad Sch Neurosci EURON, Maastricht, AZ, Netherlands
[3] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNs, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
[4] Univ Wurzburg, Div Mol Psychiat, Ctr Mental Hlth, Dept Psychiat,Lab Translat Neurosci, Wurzburg, Germany
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 73卷 / 02期
关键词：
Alzheimer's disease; deep brain stimulation; intermittent stimulation; nucleus basalis of Meynert; NEURONS; BETA;
D O I：
10.3233/JAD-190919
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.
引用
收藏
页码：461 / 466
页数：6
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