Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor

被引：34
|
作者：
Santulli, Gaetano [1 ,2 ]
Lewis, Daniel R. [1 ,2 ]
Marks, Andrew R. [1 ,2 ,3 ]
机构：
[1] Columbia Univ, Wu Ctr Mol Cardiol, New York, NY 10027 USA
[2] Columbia Univ, Coll Phys & Surg, Dept Physiol & Cellular Biophys, Med Ctr, New York, NY 10027 USA
[3] Columbia Univ, Dept Med, New York, NY 10027 USA
来源：
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY | 2017年 / 38卷 / 01期
关键词：
Calcium; Excitation-contraction coupling; Muscular dystrophy; RyR1; Skeletal muscle; CALCIUM-RELEASE CHANNEL; CENTRAL CORE DISEASE; MUSCLE SARCOPLASMIC-RETICULUM; INDUCED CA2+ RELEASE; SKELETAL-MUSCLE; MALIGNANT HYPERTHERMIA; HEART-FAILURE; INTRACELLULAR CALCIUM; CONGENITAL MYOPATHY; MOLECULAR-CLONING;
D O I：
10.1007/s10974-017-9470-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation-contraction (E-C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.
引用
收藏
页码：37 / 45
页数：9
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