Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor

被引：34
|
作者：
Santulli, Gaetano [1 ,2 ]
Lewis, Daniel R. [1 ,2 ]
Marks, Andrew R. [1 ,2 ,3 ]
机构：
[1] Columbia Univ, Wu Ctr Mol Cardiol, New York, NY 10027 USA
[2] Columbia Univ, Coll Phys & Surg, Dept Physiol & Cellular Biophys, Med Ctr, New York, NY 10027 USA
[3] Columbia Univ, Dept Med, New York, NY 10027 USA
来源：
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY | 2017年 / 38卷 / 01期
关键词：
Calcium; Excitation-contraction coupling; Muscular dystrophy; RyR1; Skeletal muscle; CALCIUM-RELEASE CHANNEL; CENTRAL CORE DISEASE; MUSCLE SARCOPLASMIC-RETICULUM; INDUCED CA2+ RELEASE; SKELETAL-MUSCLE; MALIGNANT HYPERTHERMIA; HEART-FAILURE; INTRACELLULAR CALCIUM; CONGENITAL MYOPATHY; MOLECULAR-CLONING;
D O I：
10.1007/s10974-017-9470-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation-contraction (E-C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.
引用
收藏
页码：37 / 45
页数：9
相关论文
共 50 条
  • [31] MICROTUBULES IN HEART - POSSIBLE ROLE IN EXCITATION-CONTRACTION COUPLING
    ENTMAN, ML
    GOLDSTEIN, MA
    CIRCULATION, 1976, 54 (04) : 114 - 114
  • [32] ROLE OF CALCIUM IN EXCITATION-CONTRACTION COUPLING OF LOBSTER MUSCLE
    GAINER, H
    JOURNAL OF GENERAL PHYSIOLOGY, 1968, 52 (1P1): : 88 - +
  • [33] HEART - EXCITATION-CONTRACTION COUPLING
    LANGER, GA
    ANNUAL REVIEW OF PHYSIOLOGY, 1973, 35 : 55 - 86
  • [34] Calmodulin and excitation-contraction coupling
    Hamilton, SL
    Serysheva, I
    Strasburg, GM
    NEWS IN PHYSIOLOGICAL SCIENCES, 2000, 15 : 281 - 284
  • [35] POSSIBLE ROLE OF INOSITOL TRISPHOSPHATE IN EXCITATION-CONTRACTION COUPLING
    HIDALGO, C
    CARRASCO, MA
    ROJAS, C
    JAIMOVICH, E
    ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES, 1987, 20 (02): : R153 - R153
  • [36] Phosphatases in heart: Is there a role for calcineurin in excitation-contraction coupling?
    Rogers, TB
    Gaa, ST
    duBell, WH
    FASEB JOURNAL, 1998, 12 (08): : A1405 - A1405
  • [37] ROLE OF SARCOLEMMAL PHOSPHOLIPID IN CARDIAC EXCITATION-CONTRACTION COUPLING
    LANGER, GA
    CARDIOVASCULAR RESEARCH, 1988, 22 (08) : 588 - 588
  • [38] Cardiac excitation-contraction coupling
    Bers, DM
    NATURE, 2002, 415 (6868) : 198 - 205
  • [39] Excitation-Contraction Coupling in HFpEF
    Kilfoil, Peter
    Yue, Xin
    Zhang, Rui
    Solymani, Ryan
    Soetkamp, Daniel
    Marban, Eduardo
    Goldhaber, Joshua
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 291A - 291A
  • [40] Evolution of Excitation-Contraction Coupling
    Mackrill, John James
    Shiels, Holly Alice
    CALCIUM SIGNALING, 2ND EDITION, 2020, 1131 : 281 - 320
12345