Low-cost FDM 3D-printed modular electrospray/electrospinning setup for biomedical applications

被引:12
作者
Huang, Jing [1 ]
Koutsos, Vasileios [1 ]
Radacsi, Norbert [1 ]
机构
[1] Univ Edinburgh, Inst Mat & Proc, Sch Engn, Robert Stevenson Rd, Edinburgh EH9 3FB, Midlothian, Scotland
关键词
3D printing; Low-cost; Electrospinning; Electrospray; DRUG-DELIVERY; ELECTROSPUN NANOFIBERS; TISSUE; PHARMACEUTICALS; SCAFFOLDS;
D O I
10.1186/s41205-020-00060-x
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Here, we report on the inexpensive fabrication of an electrospray/electrospinning setup by fused deposition modelling (FDM) 3D printing and provide the files and parameters needed to print this versatile device. Both electrospray and electrospinning technologies are widely used for pharmaceutical, healthcare and bioengineering applications. The setup was designed to be modular, thus its parts can be exchanged easily. The design provides a safe setup, ensuring that the users are not exposed to the high voltage parts of the setup. PLA, PVA, and a thermoplastic elastomer filament were used for the 3D printing. The filament cost was $100 USD and the rig was printed in 6days. An Ultimaker 3 FDM 3D printer was used with dual print heads, and the PVA was used as a water-soluble support structure. The end part of the setup had several gas channels, allowing a uniform gas flowing against the direction of the nanoparticles/nanofibers, enhancing the drying process by enhancing the evaporation rate. The setup was tested in both electrospray and electrospinning modes successfully. Both the .sldprt and .stl files are provided for free download.
引用
收藏
页数:7
相关论文
共 30 条
[1]  
3D4Makers Filament Engineer, WEBST PEEK FIL
[2]   3D-printed electrospinning setup for the preparation of loratadine nanofibers with enhanced physicochemical properties [J].
Ambrus, Rita ;
Alshweiat, Areen ;
Csoka, Ildiko ;
Ovari, George ;
Esmail, Ammar ;
Radacsi, Norbert .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 567
[3]   Nanofiber Assembly by Rotary Jet-Spinning [J].
Badrossamay, Mohammad Reza ;
McIlwee, Holly Alice ;
Goss, Josue A. ;
Parker, Kevin Kit .
NANO LETTERS, 2010, 10 (06) :2257-2261
[4]   Electrospun Nanofibers for Drug Delivery and Biosensing [J].
Cleeton, Conor ;
Keirouz, Antonios ;
Chen, Xianfeng ;
Radacsi, Norbert .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2019, 5 (09) :4183-4205
[5]  
Create Education Project UK, INF PROP VERB PRIM F
[6]   Cholesterol Sulfate Imaging in Human Prostate Cancer Tissue by Desorption Electrospray Ionization Mass Spectrometry [J].
Eberlin, Livia S. ;
Dill, Allison L. ;
Costa, Anthony B. ;
Ifa, Demian R. ;
Cheng, Liang ;
Masterson, Timothy ;
Koch, Michael ;
Ratliff, Timothy L. ;
Cooks, R. Graham .
ANALYTICAL CHEMISTRY, 2010, 82 (09) :3430-3434
[7]   Fatigue Behavior of FDM Parts Manufactured with Ultem 9085 [J].
Fischer, Matthias ;
Schoppner, Volker .
JOM, 2017, 69 (03) :563-568
[8]   A Bioinspired Ultraporous Nanofiber-Hydrogel Mimic of the Cartilage Extracellular Matrix [J].
Formica, Florian A. ;
Ozturk, Ece ;
Hess, Samuel C. ;
Stark, Wendelin J. ;
Maniura-Weber, Katharina ;
Rottmar, Markus ;
Zenobi-Wong, Marcy .
ADVANCED HEALTHCARE MATERIALS, 2016, 5 (24) :3129-3138
[9]  
GBIRE online store, WEBST ULT FIL
[10]  
Geoffrey R.M, 2015, ELECTROSPINNING PRIN