POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy

被引：12

作者：

Restani, Rita B. ^{[1
]}

Pires, Rita F. ^{[2
,3
]}

Tolmatcheva, Anna ^{[4
]}

Cabral, Rita ^{[4
]}

Baptista, Pedro, V ^{[4
]}

Fernandes, Alexandra R. ^{[4
]}

Casimiro, Teresa ^{[1
]}

Bonifacio, Vasco D. B. ^{[2
,3
]}

Aguiar-Ricardo, Ana ^{[1
]}

机构：

[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, LAQV,REQUIMTE, P-2829516 Caparica, Portugal

[2] Univ Lisbon, CQFM IN, P-1049001 Lisbon, Portugal

[3] Univ Lisbon, IBB, Inst Super Tecn, P-1049001 Lisbon, Portugal

[4] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Ciencias Vida, UCBIO,REQUIMTE, P-2829516 Caparica, Portugal

来源：

CHEMISTRYOPEN | 2018年 / 7卷 / 10期

关键词：

chemotherapy; composite particles; dendrimers; drug delivery; pulmonary delivery; LUNG-CANCER; INHALED DOXORUBICIN; POLYUREA DENDRIMERS; DELIVERY; PACLITAXEL; THERAPY; RELEASE;

D O I：

10.1002/open.201800093

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

POxylated polyurea dendrimer (PURE(G4)OOx(48))-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PURE(G4)OOx(48) nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.

引用

页码：772 / 779

页数：8

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