Circulating endothelial cells and their subsets: novel biomarkers for cancer

被引：5
作者：
Zhou, Fangbin [1 ,2 ]
Zhou, Yaying [3 ]
Dong, Jun [4 ]
Tan, Wenyong [1 ]
机构：
[1] Jinan Univ, Shenzhen Peoples Hosp, Dept Oncol, Clin Med Coll 2, Shenzhen 518020, Peoples R China
[2] Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China
[3] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Res Ctr, Clin Med Coll 2, Shenzhen 518020, Peoples R China
[4] Jinan Univ, Key Lab, Dept Pathophysiol, State Adm Tradit Chinese Med,Med Coll, Guangzhou 510632, Guangdong, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 08期
关键词：
angiogenesis; biomarkers; cancer; cancer therapy; circulating endothelial cells; phenotype; technical challenges; ADVANCED COLORECTAL-CANCER; METASTATIC BREAST-CANCER; HEMATOPOIETIC STEM-CELLS; PROGENITOR CELLS; PERIPHERAL-BLOOD; FLOW-CYTOMETRY; ANTIANGIOGENIC THERAPY; GROWTH-FACTOR; LUNG-CANCER; PREDICTIVE BIOMARKERS;
D O I：
10.2217/bmm-2017-0143
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Angiogenesis contributes to the growth of solid tumors. Antiangiogenic agents are widely used in various cancers and considerable efforts have been made in the development of novel biomarkers that can predict the outcome of an anticancer treatment. Of those, circulating endothelial cells (CECs) and their subsets constitute a surrogate tool for monitoring disease activity. However, owing to the lack of standardization on the phenotypes and detection of CECs and their subsets, results have always been inconsistent and uninterpretable. In this review, we focus on the biological characteristics in terms of physiology, phenotypes and detection of CECs along with their subsets; review the current scenario of CEC enumeration as a surrogate biomarker in clinical oncology; and explore their future potential applications.
引用
收藏
页码：665 / 676
页数：12
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