Circulating endothelial cells and their subsets: novel biomarkers for cancer

被引：5

作者：

Zhou, Fangbin ^{[1
,2
]}

Zhou, Yaying ^{[3
]}

Dong, Jun ^{[4
]}

Tan, Wenyong ^{[1
]}

机构：

[1] Jinan Univ, Shenzhen Peoples Hosp, Dept Oncol, Clin Med Coll 2, Shenzhen 518020, Peoples R China

[2] Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Res Ctr, Clin Med Coll 2, Shenzhen 518020, Peoples R China

[4] Jinan Univ, Key Lab, Dept Pathophysiol, State Adm Tradit Chinese Med,Med Coll, Guangzhou 510632, Guangdong, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 08期

关键词：

angiogenesis; biomarkers; cancer; cancer therapy; circulating endothelial cells; phenotype; technical challenges; ADVANCED COLORECTAL-CANCER; METASTATIC BREAST-CANCER; HEMATOPOIETIC STEM-CELLS; PROGENITOR CELLS; PERIPHERAL-BLOOD; FLOW-CYTOMETRY; ANTIANGIOGENIC THERAPY; GROWTH-FACTOR; LUNG-CANCER; PREDICTIVE BIOMARKERS;

D O I：

10.2217/bmm-2017-0143

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Angiogenesis contributes to the growth of solid tumors. Antiangiogenic agents are widely used in various cancers and considerable efforts have been made in the development of novel biomarkers that can predict the outcome of an anticancer treatment. Of those, circulating endothelial cells (CECs) and their subsets constitute a surrogate tool for monitoring disease activity. However, owing to the lack of standardization on the phenotypes and detection of CECs and their subsets, results have always been inconsistent and uninterpretable. In this review, we focus on the biological characteristics in terms of physiology, phenotypes and detection of CECs along with their subsets; review the current scenario of CEC enumeration as a surrogate biomarker in clinical oncology; and explore their future potential applications.

引用

页码：665 / 676

页数：12

共 87 条

[1] Determining circulating endothelial cells using CellSearch system during preoperative systemic chemotherapy in breast cancer patients [J].

Ali, Arwa M. ;

Ueno, Takayuki ;

Tanaka, Sunao ;

Takada, Masahiro ;

Ishiguro, Hiroshi ;

Abdellah, Ashraf Z. ;

Toi, Masakazu .

EUROPEAN JOURNAL OF CANCER, 2011, 47 (15) :2265-2272

[2] Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration [J].

Altman, Douglas G. ;

McShane, Lisa M. ;

Sauerbrei, Willi ;

Taube, Sheila E. .

PLOS MEDICINE, 2012, 9 (05)

[3] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[4] AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[5] Molecular and cellular biomarkers for angiogenesis in clinical oncology [J].

Bertolini, Francesco ;

Mancuso, Patrizia ;

Shaked, Yuval ;

Kerbel, Robert S. .

DRUG DISCOVERY TODAY, 2007, 12 (19-20) :806-812

[6] The multifaceted circulating endothelial cell in cancer: towards marker and target identification [J].

Bertolini, Francesco ;

Shaked, Yuval ;

Mancuso, Patrizia ;

Kerbel, Robert S. .

NATURE REVIEWS CANCER, 2006, 6 (11) :833-845

[7] Clinical value of circulating endothelial cells and circulating tumor cells in metastatic breast cancer patients treated first line with bevacizumab and chemotherapy [J].

Bidard, F. -C. ;

Mathiot, C. ;

Degeorges, A. ;

Etienne-Grimaldi, M. -C. ;

Delva, R. ;

Pivot, X. ;

Veyret, C. ;

Bergougnoux, L. ;

de Cremoux, P. ;

Milano, G. ;

Pierga, J. -Y. .

ANNALS OF ONCOLOGY, 2010, 21 (09) :1765-1771

[8] Circulating endothelial cells - Biomarker of vascular disease [J].

Blann, AD ;

Woywodt, A ;

Bertolini, F ;

Bull, TM ;

Buyon, JP ;

Clancy, RM ;

Haubitz, M ;

Hebbel, RP ;

Lip, GYH ;

Mancuso, P ;

Sampol, J ;

Solovey, A ;

Dignat-George, F .

THROMBOSIS AND HAEMOSTASIS, 2005, 93 (02) :228-235

[9] Increased circulating activated endothelial cells, vascular endothelial growth factor, and tumor necrosis factor in thalassemia [J].

Butthep, P ;

Rummavas, S ;

Wisedpanichkij, R ;

Jindadamrongwech, S ;

Fucharoen, S ;

Bunyaratvej, A .

AMERICAN JOURNAL OF HEMATOLOGY, 2002, 70 (02) :100-106

[10]

Cines DB, 1998, BLOOD, V91, P3527

← 1 2 3 4 5 6 7 8 9 →