Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases

被引：114

作者：

Su, Jian-Hui ^{[1
,2
]}

Luo, Meng-Yi ^{[1
,2
]}

Liang, Na ^{[3
]}

Gong, Shao-Xin ^{[4
]}

Chen, Wei ^{[1
,2
]}

Huang, Wen-Qian ^{[1
,2
]}

Tian, Ying ^{[1
]}

Wang, Ai-Ping ^{[1
,2
]}

机构：

[1] Univ South China, Hengyang Med Coll, Inst Clin Res, Affiliated Nanhua Hosp, Hengyang, Peoples R China

[2] Univ South China, Hengyang Med Coll, Hengyang Key Lab Neurodegenerat & Cognit Impairme, Inst Neurosci Res,Dept Physiol, Hengyang, Peoples R China

[3] Univ South China, Hengyang Med Coll, Affiliated Nanhua Hosp, Dept Anesthesiol, Hengyang, Peoples R China

[4] Univ South China, Hengyang Med Coll, Affiliated Hosp 5, Dept Pathol, Hengyang, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

interleukin-6; inflammation; atherosclerosis; ischemic stroke; target; IL-6R alpha; C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; HEART-FAILURE; ENDOTHELIAL DYSFUNCTION; ANGIOTENSIN-II; INFLAMMATORY CYTOKINES; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; ATRIAL-FIBRILLATION; IMMUNE-RESPONSES;

D O I：

10.3389/fphar.2021.745061

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future. This paper is aimed to discuss the expression changes and pathological mechanisms of interleukin-6 in Cardio-Cerebrovascular Diseases, and to provide a novel strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.

引用

页数：13

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