Gender-related differences in patients with bipolar disorder: a nationwide study

被引:20
作者
Buoli, Massimiliano [1 ]
Cesana, Bruno Mario [2 ]
Dell'Osso, Bernardo [3 ,4 ,5 ]
Fagiolini, Andrea [6 ,7 ]
de Bartolomeis, Andrea [8 ,9 ]
Bondi, Emi [10 ]
Maina, Giuseppe [11 ]
Bellomo, Antonello [12 ]
Altamura, A. Carlo [1 ]
机构
[1] Univ Milan, Dept Psychiat, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy
[2] Univ Milan, Dept Clin Sci & Community Hlth, Unit Med Stat Biometry & Bioinformat Giulio A Mac, Fac Med & Surg, Milan, Italy
[3] ASST Fatebenefratelli Sacco, Psychiat Unit 2, Dept Biomed & Clin Sci Luigi Sacco, Via G-B Grassi 74, I-20157 Milan, Italy
[4] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[5] Univ Milan, CRC Aldo Ravelli Neurotechnol & Expt Brain Therap, Milan, Italy
[6] Univ Siena, Med Ctr, Dept Mental Hlth, Siena, Italy
[7] Univ Siena, Med Ctr, Dept Mol Med, Siena, Italy
[8] Univ Federico II, Sch Med, Dept Neurosci Reprod Sci & Odontostomatol, Sect Psychiat, Naples, Italy
[9] Univ Federico II, Sch Med, Dept Neurosci Reprod Sci & Odontostomatol, Lab Mol & Translat Psychiat, Naples, Italy
[10] Hosp Papa Giovanni XXIII, Dept Psychiat, Bergamo, Italy
[11] Univ Turin, San Luigi Gonzaga Hosp, Dept Mental Hlth, Turin, Italy
[12] Univ Foggia, Dept Med Sci, Psychiat Unit, Foggia, Italy
关键词
Bipolar disorder (BD); clinical aspects; gender; outcome; substance abuse; SUICIDE; INTERVENTIONS; EPIDEMIOLOGY; ASSOCIATION; EPISODES; POLARITY; INSIGHT; ILLNESS; COHORT; ONSET;
D O I
10.1017/S1092852918001529
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective The possible presence of gender-related differences in patients with bipolar disorder (BD) may have diagnostic and therapeutic implications. This multicenter study aimed to investigate gender differences in BD in the largest Italian database collected to date, on behalf of the Italian Chapter of the International Society of Bipolar Disorders. Methods A total of 1674 patients (males: n = 714; females: n = 960) from different psychiatric departments were compared according to gender on demographic/clinical variables. Owing to the large number of variables statistically related to the dependent variable (gender) at the univariate analyses, preliminary multiple logistic regression analyses were performed. A final multivariable logistic regression was then performed, considering gender as the dependent variable and statistically significant demographic/clinical characteristics as independent variables. Results The results of the final multivariable logistic regression analysis with previous statistically significant demographic and clinical variables were the following: female gender was less frequently associated with employment (odds ratio [OR] = 0.7, P < 0.01), lifetime single marital status (OR = 0.45, P < 0.01), and substance abuse in the last year (OR = 0.35, P < 0.01), whereas it was more frequently associated with a major number of lifetime major depressive episodes (OR = 1.78, P < 0.01) and psychiatric visits in the last year (OR = 1.38, P = 0.01). Conclusion Few significant differences were found between genders in BD, particularly for those clinical features that are associated with poor prognosis (substance abuse for males and number of depressive episodes for females). Transcultural studies are needed to identify cultural versus illness-related variables possibly explaining the different clinical presentation of BD in relation to gender.
引用
收藏
页码:589 / 596
页数:8
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