Impact of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors on Arterial Stiffness and Vascular Aging-What Do We Know So Far? (A Narrative Review)

被引：28

作者：

Adam, Cristina Andreea ^{[1
]}

Anghel, Razvan ^{[1
,2
]}

Marcu, Dragos Traian Marius ^{[2
]}

Mitu, Ovidiu ^{[2
,3
]}

Roca, Mihai ^{[1
,2
]}

Mitu, Florin ^{[1
,2
]}

机构：

[1] Clin Rehabil Hosp, Cardiovasc Rehabil Clin, Pantelimon Halipa St 14, Iasi 700661, Romania

[2] Univ Med & Pharm, Dept Internal Med, Grigore T Popa Univ St 16, Iasi 700115, Romania

[3] Sf Spiridon Clin Emergency Hosp, Independence Blvd 1, Iasi 700111, Romania

来源：

LIFE-BASEL | 2022年 / 12卷 / 06期

关键词：

vascular aging; arterial stiffness; SGLT2; inhibitors; early vascular aging; diabetes mellitus; cardiovascular risks; ALL-CAUSE MORTALITY; OXIDATIVE STRESS; PULSE PRESSURE; CARDIOVASCULAR RISK; ENDOTHELIAL DYSFUNCTION; EXTRACELLULAR-MATRIX; BLOOD-PRESSURE; POTENTIAL MECHANISM; HEART-FAILURE; EMPAGLIFLOZIN;

D O I：

10.3390/life12060803

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vascular aging, early vascular aging or supernormal vascular aging are concepts used for estimating the cardiovascular risk at a certain age. From the famous line of Thomas Sydenham that "a man is as old as his arteries" to the present day, clinical studies in the field of molecular biology of the vasculature have demonstrated the active role of vascular endothelium in the onset of cardiovascular diseases. Arterial stiffness is an important cardiovascular risk factor associated with the occurrence of cardiovascular events and a high risk of morbidity and mortality, especially in the presence of diabetes. Sodium-glucose cotransporter 2 inhibitors decrease arterial stiffness and vascular resistance by decreasing endothelial cell activation, stimulating direct vasorelaxation and ameliorating endothelial dysfunction or expression of pro-atherogenic cells and molecules.

引用

页数：15

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